Results 161 to 170 of about 24,234 (207)

Coxsackievirus-Induced Pancreatitis

Viral Immunology, 2004
In humans, infections with the group B coxsackieviruses (CVBs) range from asymptomatic infections to chronic, debilitating diseases. The CVBs are associated with chronic inflammatory diseases of the pancreas, heart, and central nervous system. A major focus in CVB pathogenesis is to understand the mechanisms by which these viruses cause acute diseases ...
Sally, Huber, Arlene I, Ramsingh
openaire   +2 more sources

Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3

Antiviral Research, 2009
Coxsackievirus B3 (CVB-3) is a major causative agent of chronic heart muscle infections. The present study describes a cell culture system with an ongoing virus infection to evaluate two novel inhibitory strategies, either individually or combined: (1) RNA interference (RNAi) to degrade cytoplasmatic CVB-3 RNA and (2) a vector-delivered soluble variant
Jens Kurreck, Sandra Pinkert, Wolfgang Poller   +2 more
exaly   +3 more sources

The Structure of Coxsackievirus B3

1997
Picornaviruses are small, nonenveloped, icosahedral viruses. The mature virions are approximately 300 A in diameter and the interior of the capsid shell is packed with single-stranded plus sense RNA (Mw ∼ 8×106 Daltons) (Rueckert 1990). The virus capsid is composed of 60 protomers, each consisting of one copy of the viral proteins VP1, VP2, VP3 and VP4
J K, Muckelbauer, M G, Rossmann
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Coxsackievirus B4 Myocarditis in an Orangutan

Veterinary Pathology, 1999
A 37-year-old female orangutan died at the zoological garden. Autopsy examination demonstrated severe coxsackievirus B4 myocarditis immunohistochemically as a cause of the death. Apoptosis of the cardiac muscle cells was observed using the TdT-mediated dUTP-biotin nick endo labeling method and was considered to play a role in the myocarditis ...
J, Miyagi, K, Tsuhako, T, Kinjo, T, Iwamasa, Y, Kamada, T, Kinju, Y, Koyanagi   +6 more
openaire   +2 more sources

Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.

Nature structural biology, 2001
Group B coxsackieviruses (CVB) utilize the coxsackievirus-adenovirus receptor (CAR) to recognize host cells. CAR is a membrane protein with two Ig-like extracellular domains (D1 and D2), a transmembrane domain and a cytoplasmic domain. The three-dimensional structure of coxsackievirus B3 (CVB3) in complex with full length human CAR and also with the ...
Y, He, P R, Chipman, J, Howitt, C M, Bator, M A, Whitt, T S, Baker, R J, Kuhn, C W, Anderson, P, Freimuth, M G, Rossmann   +9 more
openaire   +2 more sources

Genetics of Coxsackievirus Virulence

1997
The first reported isolate of the coxsackieviruses occurred in the upstate New York town of Coxsackie (Dalldorf and Sickles 1948). By the mid-late 1950s (Dalldorf 1955), the coxsackie B viruses (CVBs) had been shown to be agents of severe human inflammatory heart muscle disease (myocarditis) (Montgomery et al. 1955; Gear et al. 1956; Javett et al. 1956;
N M, Chapman, A I, Ramsingh, S, Tracy
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The Coxsackievirus and Adenovirus Receptor

2008
The coxsackievirus and adenovirus receptor (CAR) has been studied extensively since its identification and isolation in 1997. The CAR is an immunoglobulin superfamily protein with two extracellular Ig-like domains, a single membrane-spanning sequence, and a significant cytoplasmic domain.
P, Freimuth, L, Philipson, S D, Carson
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Coxsackievirus and Congenital Malformation

JAMA: The Journal of the American Medical Association, 1967
To the Editor:— I have read with particular interest the communication by Brown and Evans, "Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease" (199: 183, 1967), because we have found a possible relation between the infections of coxsackievirus B during pregnancy and fetal deaths.
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Genetics of coxsackievirus B3 cardiovirulence.

European Heart Journal, 1995
The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent ...
Nora M Chapman, Steven Tracy, Gunter Hufnagel   +2 more
exaly   +3 more sources

Autoimmunity in Coxsackievirus Infection

2008
Abstract Viral infections frequently result in the production of autoantibodies. In most cases, these autoantibodies are low-affinity IgMs that exhibit extensive cross-reactions. Sometimes these virus-triggered immune responses progress to a pathogenic autoimmunity to form autoimmune disease.
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