Exploring the Multifractal Behavior of the Human Genome T2T-CHM13v2.0: Graphical Representations and Cytogenetics [PDF]
arXivIn this work, we applied the Chaos Game Representation (CGR) to the complete human genomic sequence T2T-CHM13v2.0, analyzing the entire chromosome assembly and each chromosome separately, including mitochondrial DNA. Multifractal spectra were determined using two types of box-counting coverage, revealing slight variations across most chromosomes. While
arxiv
Susceptibility of Nonpromoter CpG Islands to De Novo Methylation in Normal and Neoplastic Cells [PDF]
, 2001 Cuong Nguyen +8 more
openalex +1 more source
Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells
Cancer Science, EarlyView.We profiled genome‐wide DNA methylation in 1165 human cancer cell lines representing 25 cancer types and identified 73 genes as potential liver cancer‐specific methylation‐silenced genes. We selected ASNS, BCAT2, FXYD5, and NQO1 genes for further experimental analysis and demonstrated that aberrant methylation of BCAT2 contributes to the vulnerability ...
Karen Minowa +3 more
wiley +1 more source
MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands. [PDF]
BMC Genom Data, 2022 Abera B, Dinka H.
europepmc +1 more source
Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development [PDF]
, 2001 Kazuo Sakashita +6 more
openalex +1 more source
The FEBS Journal, EarlyView.Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi +12 more
wiley +1 more source
Investigation of promoter regions, motifs, and CpG islands in the regulation of gene expression in Trametes hirsuta strain 072. [PDF]
J Genet Eng Biotechnol, 2021 Senbeta D, Kebede M.
europepmc +1 more source
Species‐specific organization of CpG island promoters at mammalian homologous genes [PDF]
, 2001 Myriam Cuadrado +2 more
openalex +1 more source
Epigenetic control of cell identities from epiblast to gastrulation
The FEBS Journal, EarlyView.In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley +1 more source
Geriatrics &Gerontology International, EarlyView.Aim The Western Pacific region has the fastest aging population and 38% of the world's diabetes population. It is unknown to what extent medication management recommendations are included for older adults in type 2 diabetes (T2D) clinical practice guidelines (CPGs).
Darshna Goordeen +10 more
wiley +1 more source