Results 71 to 80 of about 869,007 (330)
CpG Island Hypermethylation in Human Astrocytomas [PDF]
Cancer Research, 2010 Abstract Astrocytomas are common and lethal human brain tumors. We have analyzed the methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain and in astrocytomas of various grades using the methylated CpG island recovery assay.
Xueyan Zhong +6 more
openaire +3 more sources
Role of time reversal symmetry and tilting in circular photogalvanic responses [PDF]
Phys. Rev. B 103, 144308 (2021), 2020 We study the role of time reversal symmetry (TRS) in the circular photogalvanic (CPG) responses considering chiral Weyl semimetal (WSM) while a quantized CPG response is guaranteed by broken of both inversion symmetry (IS) and mirror symmetries. The TRS broken WSM yields one left and one right chiral Weyl nodes (WNs) while there are two left and right ...
arxiv +1 more source
Predicting aberrant CpG island methylation [PDF]
Proceedings of the National Academy of Sciences, 2003 Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of ...
Christoph Plass +5 more
openaire +3 more sources
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Schematic depicting mechanism by which HPC protects neurons against tGCI in CA1 through Piwil2‐mediated epigenetics. Abstract Epigenetic modification contributes to the pathogenesis of cerebral ischemia. Piwil2 belongs to the PIWI proteins subfamily and has a key role in the regulation of gene transcription through epigenetics.
Lixuan Zhan +8 more
wiley +1 more source
Reinforcement Learning of CPG-regulated Locomotion Controller for a Soft Snake Robot [PDF]
, 2022 Intelligent control of soft robots is challenging due to the nonlinear and difficult-to-model dynamics. One promising model-free approach for soft robot control is reinforcement learning (RL). However, model-free RL methods tend to be computationally expensive and data-inefficient and may not yield natural and smooth locomotion patterns for soft robots.
arxiv +1 more source
MIRA-seq for DNA methylation analysis of CpG islands
Epigenomics, 2015 Aim: To develop a reliable method for whole genome analysis of DNA methylation. Materials & methods: Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins.
Marc Jung +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
eLife, 2018 CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and
Emilia Dimitrova +8 more
doaj +1 more source
Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]
Bioinformatics 30 (2014) i408-i414, 2014 Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation. Genome-wide DNA methylation assays have become increasingly common, and recently distinct stages across differentiating cellular lineages have been ...
arxiv +1 more source
Synthetic CpG islands reveal DNA sequence determinants of chromatin structure
eLife, 2014 The mammalian genome is punctuated by CpG islands (CGIs), which differ sharply from the bulk genome by being rich in G + C and the dinucleotide CpG. CGIs often include transcription initiation sites and display ‘active’ histone marks, notably histone H3 ...
Elisabeth Wachter +6 more
semanticscholar +1 more source