Results 71 to 80 of about 71,046 (242)

Methylated-CpG Island Recovery Assay [PDF]

, 2011
Alterations in DNA methylation patterns are implicated in playing a major role in the development of cancer, thus highlighting the need to continually develop new technologies to analyze epigenetic marks. Methylated-CpG Island Recovery Assay (MIRA), based on the high affinity of the MBD2b/MDB3L1 complex for double-stranded methylated DNA, allows for ...
Natalie, Mitchell, J Tyson, Deangelis, Trygve O, Tollefsbol   +2 more
openaire   +2 more sources

Reading hominin life history in fossil bones and teeth: methods to test hypotheses regarding its evolution

Biological Reviews, EarlyView.
ABSTRACT Human life history is derived compared to that of our closest living relatives, the great apes. It has been suggested that these derived traits are causally related to aspects of our ecology, social behaviour and cognitive abilities. However, resolving this requires that we know the evolutionary trajectory of our distinctive pattern of growth,
Paola Cerrito, Judith M. Burkart, Carel van Schaik   +2 more
wiley   +1 more source

Spreadsheet-Based Program for the Analysis of DNA Methylation

BioTechniques, 2001
Methylation of DNA in CpG dense regions of gene promoters (CpG islands) is important for transcriptional inactivation of selective genes in normal and neoplastic cells.
Ramaswamy Anbazhagan, James G. Herman, Kalyan Enika, Edward Gabrielson   +3 more
doaj   +1 more source

CpG Island Hypermethylation in Human Astrocytomas [PDF]

Cancer Research, 2010
Abstract Astrocytomas are common and lethal human brain tumors. We have analyzed the methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain and in astrocytomas of various grades using the methylated CpG island recovery assay.
Xiwei, Wu, Tibor A, Rauch, Xueyan, Zhong, William P, Bennett, Farida, Latif, Dietmar, Krex, Gerd P, Pfeifer   +6 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source

Demographic and Clinical Characteristics of Early‐Onset Colorectal Cancer in Sweden and Finland: A Multicentre Retrospective Cohort Study Over Three Decades

Journal of Surgical Oncology, EarlyView.
ABSTRACT Colorectal cancer is the third most common cancer worldwide, and the proportion of individuals diagnosed under the age of 50 years, referred to as early‐onset colorectal cancer (EOCRC), is increasing. The aim of this study was to evaluate how the demographic and clinical features of EOCR in northern Sweden and Finland have changed over time ...
Melina Charalambidi, Tanja Hukkinen, Tuomas Kaprio, Sofia Edin, Mats Hjortborg, Cecilia Williams, Jaana Hagström, Caj Haglund, Richard Palmqvist, Karin Strigård, Camilla Böckelman, Ioannis Gkekas   +11 more
wiley   +1 more source

An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21

, 2004
An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb.
Aaltonen, Aaltonen, Arques, Baldi, Bernardi, Bernardi, Borodovsky, Burge, Clay, Clay, Clay, Dirk Holste, Fickett, Fukushima, Golfier, Grosse, Guigo, Hattori, Herzel, Holste, Konopka, Larsen, Li, Li, Li, Macaya, McKusick, Nagamine, Nekrutenko, Oliver, Oliver, Pavlícek, Pizzi, Saccone, Shiba, Shulman, Smit, Staden, Tiwari, Tomita, Trifonov, Trifonov, Wentian Li, Widom, Zhurkin   +44 more
core   +2 more sources

Large-scale structural analysis of the core promoter in mammalian and plant genomes [PDF]

, 2005
DNA encodes at least two independent levels of functional information. The first level is for encoding proteins and sequence targets for DNA-binding factors, while the second one is contained in the physical and structural properties of the DNA molecule ...
Florquin, Kobe, Saeys, Yvan, Degroeve, Sven, Rouzé, Pierre, Van de Peer, Yves   +4 more
core   +1 more source

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source