Results 81 to 90 of about 28,422 (165)

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

CpG Islands and Double-Minute Chromosomes

Genomics, 1998
Double-minute chromosomes (DMs) amplify oncogenes in human tumors. The organization of genomic DNA in four independently isolated DMs amplifying the DHFR (dihydrofolate reductase) gene has been compared by mapping locations of CpG islands. When cleaved with methylation-sensitive rare-cutting restriction endonucleases, three hypomethylated GC-rich DNA ...
Peter J. Hahn, Rabia Rizwana
openaire   +3 more sources

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Tumor regression grade (TRG) is an essential prognostic factor in determining treatment efficacy. However, the potential factors influencing TRG in patients with rectal cancer who have received NACRT have not been ...
Jen‐Pin Chuang, Hsiang‐Lin Tsai, Po‐Jung Chen, Ching‐Wen Huang, Wei‐Chih Su, Tsung‐Kun Chang, Yen‐Cheng Chen, Ching‐Chun Li, Yung‐Sung Yeh, Jaw‐Yuan Wang   +9 more
wiley   +1 more source

The Echinococcus canadensis (G7) genome: A key knowledge of parasitic platyhelminth human diseases [PDF]

, 2017
Background: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which ...
A Bankevich, A Gurevich, A Lomsadze, A Lomsadze, Adolfo Fox, AM Bolger, Anna C. M. Salim, B Hendrich, B Langmead, C Bermudez-Santana, C Hahn, C Holt, C Jiang, C Trapnell, CA Alvarez Rojas, CCM Budke, D Kim, D Takai, DP McManus, DR Zerbino, E Elkayam, E Keibler, E Quevillon, F Jeanmougin, F Kiefer, F Mohn, Federico Camicia, Flávio M. Gomes Araújo, G Abrusán, G Parra, GSC Slater, Guilherme Oliveira, H Li, H Zheng, I Korf, IJ Tsai, IJ Tsai, J Eckert, JK Nono, JM Bart, JP Hewitson, Juliana Assis, K Arnold, K Matsuo, K Thivierge, K Wasik, KJ Fryxell, KK Geyer, KK Geyer, L Han, L Han, L Kamenetzky, L Kamenetzky, L Kamenetzky, L Li, LA Kelley, Laura Kamenetzky, LD Moore, Lucas L. Maldonado, M Ashburner, M Biasini, M Cucher, M Cucher, M Krzywinski, M Marín, M Nakao, M Nakao, M Nakao, M Nakao, M Nakao, M Rosenzvit, M Sajid, M Stanke, MA Cucher, Mara Rosenzvit, Marcela Cucher, MC Rosenzvit, MW Robinson, N Guex, N Macchiaroli, N Schürmann, Natalia Macchiaroli, ND Young, O Bogdanović, P Carninci, P Cingolani, P Danecek, PM Muzulin, PM Schantz, PS Craig, R Luo, R Schneider, RD Finn, RJ Klose, S Assefa, S Maillard, S Saxonov, S Yi, SF Altschul, SM Sadjjadi, TD Otto, TD Otto, TM Lowe, U Koziol, U Saarma, W Pan, Y Moriya, Y Safonova, YA Medvedeva, Z Zhao   +109 more
core   +8 more sources

Advances and Challenges in Pluripotent Stem Cell‐Based Whole‐Cell Vaccines for Cancer Treatment

Medicine Bulletin, EarlyView.
ABSTRACT In recent decades, an unexpected application of pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), as a novel source for whole‐cell vaccines (WCVs) against cancer has attracted attention in the field of tumor immunotherapy.
Guoyue Wan, Jian‐Dong Huang, Ren‐He Xu, Meiling Jin   +3 more
wiley   +1 more source

Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats

Molecular Nutrition &Food Research, EarlyView.
Excessive intake of saturated fats during pregnancy is associated with DNA hypomethylation in placental and cord blood samples from women affected with gestational diabetes mellitus (GDM), impacting, in particular, the cord blood promoter of ZFP57, a key regulator of early embryonic epigenetic programming.
Fatima Ahmad, Sidra Aftab Uzair, Arun P. Lakshmanan, Shaikha Alabduljabbar, Salma H. Ahmed, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Rose McGready, François Nosten, Damien Chaussabel, Souhaila Al Khodor, Annalisa Terranegra   +13 more
wiley   +1 more source

Impact of Tandem Repeats on the Scaling of Nucleotide Sequences

, 2005
Techniques such as detrended fluctuation analysis (DFA) and its extensions have been widely used to determine the nature of scaling in nucleotide sequences.
Bashir R., Doggett N. A., MEENAKSHI UPRETI, RADHAKRISHNAN NAGARAJAN, Tavare S.   +4 more
core   +1 more source

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

VIEW, EarlyView.
Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) poses a significant public health risk, yet effective treatments are limited due to the lack of suitable models. This study developed a more realistic model of SI‐ALI using organ‐on‐a‐chip and organoid technologies, identified key molecules such as catechol‐O‐methyltransferase and ...
Junmin Li, Dezhong Zhang, Yan Meng, Yongqing Chang, Wenbo Wei, Peng Wu, Lin Peng, Wei Chang, Wei Wang, Jie Huang, Jingjing Fang, Keming Zhu, Xiaojian Wan   +12 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source