Results 81 to 90 of about 869,007 (330)

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness

Genome Biology, 2018
Background Population phenotypic variation can arise from genetic differences between individuals, or from cellular heterogeneity in an isogenic group of cells or organisms. The emergence of gene expression differences between genetically identical cells
Michael D. Morgan, John C. Marioni
doaj   +1 more source

Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression

Epigenetics & Chromatin, 2014
BackgroundDNA methylation is thought to play an important role in the regulation of mammalian gene expression, partly based on the observation that a lack of CpG island methylation in gene promoters is associated with high transcriptional activity ...
R. Edgar, Powell Patrick Cheng Tan, Elodie Portales-Casamar, P. Pavlidis   +3 more
semanticscholar   +1 more source

Frequency‐Dependent Demethylation of Cancer DNAs by High‐Power Terahertz Radiation

Advanced Photonics Research, EarlyView.
Effective demethylation of cancer DNA is successfully demonstrated by resonant irradiation with high‐power terahertz (THz) waves at the 10 mW level, combined with metamaterial‐based THz filters. The dependence of spectral filtering on demethylation indicates that the resonant frequency of 1.6 THz of cancer DNAs plays a crucial role in reducing the ...
Chaeyoon Kim, Seung Won Jin, Seong Cheol Lee, Donghak Oh, Soojeong Baek, Bumki Min, Hee‐Jin Yang, Joo‐Hiuk Son, Fabian Rotermund   +8 more
wiley   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

A Deep Embedded Refined Clustering Approach for Breast Cancer Distinction based on DNA Methylation [PDF]

arXiv, 2021
Epigenetic alterations have an important role in the development of several types of cancer. Epigenetic studies generate a large amount of data, which makes it essential to develop novel models capable of dealing with large-scale data. In this work, we propose a deep embedded refined clustering method for breast cancer differentiation based on DNA ...
arxiv  

Number of CpG islands and genes in human and mouse.

Proceedings of the National Academy of Sciences of the United States of America, 1993
Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study, we provide a direct measurement of the number of genes in human and mouse.
F. Antequera, A. Bird
semanticscholar   +1 more source

In vitromethylation of CpG-rich islands

Nucleic Acids Research, 1989
CpG islands are distinguishable from the bulk of vertebrate DNA for being unmethylated and CpG-rich. Since CpG doublets are the specific target of eukaryotic DNA methyltransferases, CpG-rich sequences might be expected to be good methyl-accepting substrates in vitro, despite their unmethylated in vivo condition.
CAROTTI, Daniela, PALITTI, Franco, LAVIA P, STROM, Roberto   +3 more
openaire   +6 more sources

CpGIF: an algorithm for the identification of CpG islands [PDF]

Bioinformation, 2008
CpG islands (CGIs) play a fundamental role in genome analysis and annotation, and contribute to improving the accuracy of promoter prediction. Besides, CGIs in promoter regions are abnormally methylated in cancer cells and thus can be used as tumor markers. However, current methods for identifying CGIs suffer from various drawbacks.
Asai Asaithambi, Yunkai Liu, Ye Sujuan
openaire   +3 more sources

Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults. [PDF]

PLoS ONE, 2015
Monozygotic twins share identical genomic DNA and are indistinguishable using conventional genetic markers. Increasing evidence indicates that monozygotic twins are epigenetically distinct, suggesting that a comparison between DNA methylation patterns ...
Na Zhang, Shumin Zhao, Su-Hua Zhang, Jinzhong Chen, Daru Lu, Min Shen, Chengtao Li   +6 more
doaj   +1 more source