Results 61 to 70 of about 146 (99)

Emerging Roles of Biomolecular Condensates in Pre‐mRNA 3′ End Processing

WIREs RNA, Volume 16, Issue 4, July/August 2025.
Pre‐mRNA 3′ end processing factors can self‐assemble into biomolecular condensates that fine‐tune pre‐mRNA cleavage and polyadenylation, and their misregulation underlies disease. Nuclear speckles and histone locus bodies spatially compartmentalize distinct 3′ end reactions to ensure efficient gene expression control.
Yoseop Yoon, Liang Liu, Cailyx Quan, Yongsheng Shi   +3 more
wiley   +1 more source

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang, Ben J. Hayes, Russell E. Lyons, Imtiaz A. S. Randhawa, John B. Gaughan, Nguyen X. Trach, David M. McNeill   +6 more
wiley   +1 more source

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6 [PDF]

Nucleic Acids Research, 2019
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor 5 (CPSF5) and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA). Loss of CFIm function results in proximal polyadenylation site usage, shortening mRNA 3' untranslated regions (UTRs). Although CPSF6 plays additional roles
Sooin Jang, Nicola J Cook, Valerie E Pye, Gregory J Bedwell, Amanda M Dudek, Parmit K Singh, Peter Cherepanov, Alan N Engelman   +7 more
openaire   +4 more sources

Phenotypic Characterization of Replication‐Impaired Lenacapavir‐Resistant HIV Clinical Isolates

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Lenacapavir (LEN) is a potent, first‐in‐class long‐acting HIV‐1 capsid (CA) inhibitor, approved for treatment of people with multi‐drug resistant HIV in combination with other antiretrovirals. In clinical studies with LEN, the CA resistance‐associated mutations (RAMs) M66I, Q67H/K/N, K70H/N/R/S, N74D/H/K, A105S/T, and T107A/C/N/S were observed.
Sally Demirdjian, Vidula Naik, Nicolas Margot, Brie Falkard, Christian Callebaut   +4 more
wiley   +1 more source

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles

eLife
Viruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighbouring chromatin, promoting high transcription rates and ...
Chiara Tomasini, Celine Cuche, Selen Ay, Maxence Collard, Bin Cui, Mohammad Rashid, Shaoni Bhattacharjee, Bruno Tello-Rubio, Julian Buchrieser, Charlotte Luchsinger, Cinzia Bertelli, Vladimir Uversky, Felipe Diaz-Griffero, Francesca Di Nunzio   +13 more
doaj   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells.

PLoS Pathogens
Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV ...
Daphne Cornish, Kathryn A Jackson-Jones, Ted Ling-Hu, Lacy M Simons, William J Cisneros, Edmund Osei Kuffour, Natalie Stegman, Francesca Agnes, Yujin Lee, Ved P Sharma, Paul D Bieniasz, Ramon Lorenzo-Redondo, Judd F Hultquist   +12 more
doaj   +1 more source

Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR‐615‐3p‐PICK1 interaction

BioFactors, Volume 51, Issue 1, January/February 2025.
Vimentin affects the miR‐615‐3p‐PICK1 axis via APA, highlighting its role in cancer progression in TNBC. The findings show the interplay between VIM, miR‐615‐3p, and PICK1 and open new avenues for targeted cancer therapy. Abstract Breast cancer continues to be a major health issue for women worldwide, with vimentin (VIM) identified as a crucial factor ...
Xinyan Jia, Lujing Shao, Hong Quan, Zhixian Zhong, Chunyan Dong   +4 more
wiley   +1 more source

Identification of pathological pathways centered on circRNA dysregulation associated with early pathogenic progression of Alzheimer’s disease

Alzheimer's &Dementia, Volume 20, Issue S1, December 2024.
Abstract Background Circular RNAs (circRNAs) play multifaceted roles to precisely control expression of broad gene networks. These highly stable molecules are often accumulated in the mammalian brain and thought to serve as “memory molecules” that govern the long process of aging.
Feng Wang, Yangping Li, Huifeng Shen, Yue Feng, Bing Yao   +4 more
wiley   +1 more source

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

Nature Communications, 2023
HIV-1 capsid (CA) stability is important for viral replication. E45A and P38A mutations enhance and reduce core stability, thus impairing infectivity. Second-site mutations R132T and T216I rescue infectivity.
Anna T. Gres, Karen A. Kirby, William M. McFadden, Haijuan Du, Dandan Liu, Chaoyi Xu, Alexander J. Bryer, Juan R. Perilla, Jiong Shi, Christopher Aiken, Xiaofeng Fu, Peijun Zhang, Ashwanth C. Francis, Gregory B. Melikyan, Stefan G. Sarafianos   +14 more
doaj   +1 more source