Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline [PDF]
Amino AcidsCollapsin response mediator protein 2 (CRMP2) functions in the genesis and activity of neuronal connections in mammalian brain. We previously reported that a protein coincident with CRMP2 on 2D-gels undergoes marked accumulation of abnormal L-isoaspartyl
Jeff X. Zhu, Dana W. Aswad
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Trio and CRMP2 regulate axon branching and Semaphorin3A signaling [PDF]
Communications BiologyTrio is a neuronally expressed, Rac1- and RhoA-activating RhoGEF, that is required for neurodevelopment. Mutations affecting the Rac1-activating GEF domain of Trio are associated with profound neurodevelopmental delay and Trio knock-out is embryonic ...
Erin Fingleton +5 more
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Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model [PDF]
CellsWe explored how the phosphorylation state of collapsin response mediator protein 2 (CRMP2) influences mitochondrial functions in cultured cortical neurons and cortical synaptic mitochondria isolated from APP-SAA KI mice, a knock-in APP mouse model of ...
Tatiana Brustovetsky +2 more
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Collapsin Response Mediator Protein 2 (CRMP2) Modulates Induction of the Mitochondrial Permeability Transition Pore in a Knock-In Mouse Model of Alzheimer’s Disease [PDF]
CellsHyperphosphorylated collapsin response mediator protein 2 (CRMP2) is elevated in the cerebral cortex of an APP-SAA knock-in mouse model of Alzheimer’s disease and binds the adenine nucleotide translocase (ANT) in a phosphorylation-dependent manner.
Tatiana Brustovetsky +2 more
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Effect of lidocaine on cognitively impaired rats: Anti‐inflammatory and antioxidant mechanisms in combination with CRMP2 antiphosphorylation [PDF]
Immunity, Inflammation and Disease, 2023 Objective Studies have shown that lidocaine has antioxidative stress, anti‐inflammatory, and nerve‐protective effects. The current study investigated the effects of lidocaine on cognitive function in rats with cognitive dysfunction. Methods A total of 48
Xiaohong Zheng +3 more
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Effects of esketamine on depression-like behavior and dendritic spine plasticity in the prefrontal cortex neurons of spared nerve injury-induced depressed mice [PDF]
Brazilian Journal of Medical and Biological ResearchThe present study utilized the spared nerve injury (SNI) to create a mouse model of depression to investigate the impact of esketamine on depressive-like behaviors, on the expression of PSD-95 and CRMP2 proteins, and on changes in neuronal dendritic ...
Bixin Huang +4 more
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CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons
Cells, 2021 Regulation of mitochondrial morphology and motility is critical for neurons, but the exact mechanisms are unclear. Here, we demonstrate that these mechanisms may involve collapsin response mediator protein 2 (CRMP2).
Tatiana Brustovetsky +2 more
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Implication of Adipogenesis-Coupled CRMP2 Functional Profile in Metabolic Homeostasis and Imbalance
Biomedicines, 2022 Our previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) is associated with obesity and, in addition, that hyperglycemia-suppressed CRMP2 augments malignant traits of colorectal cancer and is associated with advanced tumor ...
Yih-Hsin Chang +7 more
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Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission [PDF]
, 2013 Efficient HTLV-1 viral transmission occurs through cell-to-cell contacts. The Tax viral transcriptional activator protein facilitates this process. Using a comparative transcriptomic analysis, we recently identified a series of genes up-regulated in HTLV-
Afonso, PV +7 more
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Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease
Cells, 2021 Mitochondrial morphology and motility (mitochondrial dynamics) play a major role in the proper functioning of distant synapses. In Huntington’s disease (HD), mitochondria become fragmented and less motile, but the mechanisms leading to these changes are ...
Tatiana Brustovetsky +2 more
doaj +1 more source