Results 91 to 100 of about 3,056 (192)
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source
Molecular Brain, 2020 Calcium dysregulation is a key pathological event in Alzheimer’s disease (AD). In studying approaches to mitigate this calcium overload, we identified the collapsin response mediator protein 2 (CRMP2), an axonal guidance protein that participates in ...
Baochang Qi +6 more
doaj +1 more source
Epilepsia, Volume 66, Issue 5, Page 1599-1612, May 2025.Abstract Objective Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, left lateralization. Examining the integrity of white matter pathways involved in the adaptation or maintenance of language lateralization in these patients could have important clinical implications for preserving
Salvatore Citro +7 more
wiley +1 more source
, 2019 Figure S2: Site-specific O-GlcNAc-CRMP2 antibody (OG-CRMP2) recognises Ser517 O-GlcNAcylated CRMP2 in vitro and in vivo. (a) Western blot on in vitro glycosylated recombinant CRMP2 using the OG-CRMP2 antibody. Lack of signal on non-O-GlcNAcylated and Ser517Ala CRMP2 samples indicates that the antibody is specific. (b) Western blot on mouse brain lysate
Villo Muha +13 more
openaire +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
Deciphering the role of sphingosine 1‐phosphate in central nervous system myelination and repair
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Sphingosine‐1‐phosphate (S1P) signals to a family of five S1P receptors 1–5 (S1PR1–5) coupled with different G proteins. Current studies indicate that S1P exerts differential effects on oligodendrocytes (OLG) and myelin depending on the receptor being activated: promoting the survival of oligodendrocyte precursor cells (OPC) via activating S1PR1 whilst
Fatima Binish, Junhua Xiao
wiley +1 more source
Cell Death Discovery, 2022 Dysfunction of ionotropic glutamate receptors (iGluRs) is a key molecular mechanism of excitotoxic neuronal injury following traumatic brain injury (TBI).
Tao Chen +5 more
doaj +1 more source
Poly-arginine peptide R18D reduces neuroinflammation and functional deficits following traumatic brain injury in the Long-Evans rat [PDF]
, 2019 We have previously demonstrated that the poly-arginine peptide R18 can improve histological and functional outcomes following traumatic brain injury (TBI) in the Sprague–Dawley rat.
Anderton, Ryan S +5 more
core +1 more source
International Journal of Clinical Practice, Volume 2025, Issue 1, 2025.Purpose: Calcitonin gene‐related peptide (CGRP) is a key peptide released during trigeminal system‐initiated migraine attacks. Evidence suggests that lacosamide can inhibit CGRP release. This study aimed to assess the effectiveness of lacosamide in patients with chronic migraine. Methods: This double‐blind, randomized clinical study involved 83 chronic
Mobina Mirhosseini +4 more
wiley +1 more source
Cell Communication and Signaling, 2023 Elraglusib (formerly 9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3β (GSK3β) undergoing clinical trials for the treatment of various cancers including non-Hodgkin lymphoma (NHL). The drug reduces proliferation of several NHL cell
Josh T. Coats +2 more
doaj +1 more source