Results 11 to 20 of about 3,056 (192)

GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility [PDF]

Frontiers in Immunology, 2021
The trafficking of T-cells through peripheral tissues and into afferent lymphatic vessels is essential for immune surveillance and an adaptive immune response.
Mobashar Hussain Urf Turabe Fazil, Praseetha Prasannan, Brandon Han Siang Wong, Brandon Han Siang Wong, Amuthavalli Kottaiswamy, Nur Syazwani Binte Mohamed Salim, Siu Kwan Sze, Navin Kumar Verma   +7 more
doaj   +5 more sources

CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration [PDF]

Biomolecules, 2021
Collapsin response mediator protein 2 (CRMP2) is an adaptor protein that adds tubulin dimers to the growing tip of a microtubule. First described in neurons, it is now considered a ubiquitous protein that intervenes in processes such as cytoskeletal ...
Xabier Morales, Rafael Peláez, Saray Garasa, Carlos Ortiz de Solórzano, Ana Rouzaut   +4 more
doaj   +4 more sources

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury [PDF]

Molecular Brain, 2020
Effective treatment of high-impact pain patients is one of the major stated goals of the National Pain Strategy in the United States. Identification of new targets and mechanisms underlying neuropathic pain will be critical in developing new target ...
Aubin Moutal, Yingshi Ji, Shreya Sai Bellampalli, Rajesh Khanna   +3 more
doaj   +3 more sources

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer’s Disease

Cells, 2023
Mitochondrial bioenergetics and dynamics (alterations in morphology and motility of mitochondria) play critical roles in neuronal reactions to varying energy requirements in health and disease.
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +4 more sources

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells. [PDF]

J Neurosci Res
LKE increased OPC proliferation and maturation. LKE reduced Ca responses to ATP and glutamate, and increased responses to KCl. Similar effects occurred with a peptide that disrupts Collapsin Response Mediator Protein 2 interactions with NMDARs and VGCCs.
Cheli VT, Tumuluri SG, McDonald Z, Denton TT, Dupree JL, Paez PM, Feinstein DL.   +6 more
europepmc   +2 more sources

Bioinformatics Analysis of Persistent Dysregulated Expression of Genes Involved in HCV-Induced Neurological Disorders and Liver Injuries After DAA Treatment Through Weighted Gene Co-Expression Network Analysis. [PDF]

Health Sci Rep
ABSTRACT Background and Aims The molecular processes involved in the progression of neuropsychiatric and liver disorders in some patients who have achieved sustained virologic response after successful DAA treatment are still unclear. To understand these processes, we investigated alterations in the transcription patterns of genes associated with ...
Ghobadi MZ, Esfehani MAN, Shahmahmoodi S, Nejati A, Keshavarz A, Samimi-Rad K.   +5 more
europepmc   +2 more sources

Autoantibodies Against Collapsin Response Mediator Proteins Associated With Encephalopathy/Myelopathy: A Single-Center Retrospective Study. [PDF]

CNS Neurosci Ther
This is a study to assess autoantibodies against CRMPs in a cohort of 400 patients with encephalopathy/myelopathy by CBA and TBA tests. Anti‐CRMPs Abs may indicate immune‐mediated neuronal damage in encephalopathy/myelopathy. ABSTRACT Background Collapsin response mediator protein (CRMP) consists of five subtypes (CRMP1–5), which share high homology ...
Wang D, Wang Q, Jie S, Liu G, Huang X, Pan Y, Xu K, Chen C, Huang Y, Jiang Y, Chen Z, Deng W, He F, Dai C, Pan S, Wu Y, Hu Y.   +16 more
europepmc   +2 more sources

Blocking CRMP2 SUMOylation reverses neuropathic pain [PDF]

Molecular Psychiatry, 2017
Collapsin response mediator proteins 1−5 (CRMPs1−5) are a family of cytosolic proteins that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine development and synaptic plasticity (reviewed in Khanna et al.1and Quach et al.2).
A, Moutal, E T, Dustrude, T M, Largent-Milnes, T W, Vanderah, M, Khanna, R, Khanna   +5 more
openaire   +2 more sources

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission [PDF]

Molecular Neurobiology, 2018
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states.
Jie Yu, Aubin Moutal, Angie Dorame, Shreya S. Bellampalli, Aude Chefdeville, Iori Kanazawa, Nancy Y. N. Pham, Ki Duk Park, Jill M. Weimer, Rajesh Khanna   +9 more
openaire   +2 more sources

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Liz, Márcia A., Mar, Fernando M., Marques, Ana M., Morgado, Marlene M., Pemble, Hayley, Pimentel, Helena I., Santos, Telma E., Sousa, Mónica M., Sousa, Vera F., Sutherland, Calum, Vieira, Sílvia, Wittmann, Torsten, Woodgett, James R.   +12 more
core   +16 more sources