Results 11 to 20 of about 3,047 (190)

GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility [PDF]

Frontiers in Immunology, 2021
The trafficking of T-cells through peripheral tissues and into afferent lymphatic vessels is essential for immune surveillance and an adaptive immune response.
Mobashar Hussain Urf Turabe Fazil, Praseetha Prasannan, Brandon Han Siang Wong, Brandon Han Siang Wong, Amuthavalli Kottaiswamy, Nur Syazwani Binte Mohamed Salim, Siu Kwan Sze, Navin Kumar Verma   +7 more
doaj   +5 more sources

CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration [PDF]

Biomolecules, 2021
Collapsin response mediator protein 2 (CRMP2) is an adaptor protein that adds tubulin dimers to the growing tip of a microtubule. First described in neurons, it is now considered a ubiquitous protein that intervenes in processes such as cytoskeletal ...
Xabier Morales, Rafael Peláez, Saray Garasa, Carlos Ortiz de Solórzano, Ana Rouzaut   +4 more
doaj   +4 more sources

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer’s Disease

Cells, 2023
Mitochondrial bioenergetics and dynamics (alterations in morphology and motility of mitochondria) play critical roles in neuronal reactions to varying energy requirements in health and disease.
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +4 more sources

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury [PDF]

Molecular Brain, 2020
Effective treatment of high-impact pain patients is one of the major stated goals of the National Pain Strategy in the United States. Identification of new targets and mechanisms underlying neuropathic pain will be critical in developing new target ...
Aubin Moutal, Yingshi Ji, Shreya Sai Bellampalli, Rajesh Khanna   +3 more
doaj   +3 more sources

Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis [PDF]

Life Science Alliance, 2019
Enhanced carbonyl stress results in neurodevelopmental deficits by affecting microtubule function through the formation of irreversible dysfunctional multimer of carbonylated CRMP2.
Manabu Toyoshima, Xuguang Jiang, Tadayuki Ogawa, Tetsuo Ohnishi, Shogo Yoshihara, Shabeesh Balan, Takeo Yoshikawa, Nobutaka Hirokawa   +7 more
doaj   +3 more sources

Baishaoluoshi Decoction Mitigates Post-Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo-A/NgR Signaling Pathway. [PDF]

Brain Behav
Baishaoluoshi Decoction alleviates post‐stroke spasticity by downregulating inhibitory proteins (Nogo‐A/NgR) in the peri‐infarct brain region and reducing NgR/Olig2 co‐localization in oligodendrocytes, thereby enhancing synaptic plasticity. ABSTRACT Objective: This study systematically investigated the effects and molecular mechanisms of Baishaoluoshi ...
Sun X, Zeng S, Lin S, Wu L, Tang X, Zhu J, Zhang Y, Li L, Chen Z, Deng X, Wu D, Xie L.   +11 more
europepmc   +2 more sources

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells. [PDF]

J Neurosci Res
LKE increased OPC proliferation and maturation. LKE reduced Ca responses to ATP and glutamate, and increased responses to KCl. Similar effects occurred with a peptide that disrupts Collapsin Response Mediator Protein 2 interactions with NMDARs and VGCCs.
Cheli VT, Tumuluri SG, McDonald Z, Denton TT, Dupree JL, Paez PM, Feinstein DL.   +6 more
europepmc   +2 more sources

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal-Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma. [PDF]

CNS Neurosci Ther
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Beard E, El-Bushra S, Kader Z, Sun YJ, Au NPB.   +4 more
europepmc   +2 more sources

Bioinformatics Analysis of Persistent Dysregulated Expression of Genes Involved in HCV-Induced Neurological Disorders and Liver Injuries After DAA Treatment Through Weighted Gene Co-Expression Network Analysis. [PDF]

Health Sci Rep
ABSTRACT Background and Aims The molecular processes involved in the progression of neuropsychiatric and liver disorders in some patients who have achieved sustained virologic response after successful DAA treatment are still unclear. To understand these processes, we investigated alterations in the transcription patterns of genes associated with ...
Ghobadi MZ, Esfehani MAN, Shahmahmoodi S, Nejati A, Keshavarz A, Samimi-Rad K.   +5 more
europepmc   +2 more sources

Autoantibodies Against Collapsin Response Mediator Proteins Associated With Encephalopathy/Myelopathy: A Single-Center Retrospective Study. [PDF]

CNS Neurosci Ther
This is a study to assess autoantibodies against CRMPs in a cohort of 400 patients with encephalopathy/myelopathy by CBA and TBA tests. Anti‐CRMPs Abs may indicate immune‐mediated neuronal damage in encephalopathy/myelopathy. ABSTRACT Background Collapsin response mediator protein (CRMP) consists of five subtypes (CRMP1–5), which share high homology ...
Wang D, Wang Q, Jie S, Liu G, Huang X, Pan Y, Xu K, Chen C, Huang Y, Jiang Y, Chen Z, Deng W, He F, Dai C, Pan S, Wu Y, Hu Y.   +16 more
europepmc   +2 more sources