Results 21 to 30 of about 3,047 (190)

Blocking CRMP2 SUMOylation reverses neuropathic pain [PDF]

Molecular Psychiatry, 2017
Collapsin response mediator proteins 1−5 (CRMPs1−5) are a family of cytosolic proteins that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine development and synaptic plasticity (reviewed in Khanna et al.1and Quach et al.2).
A, Moutal, E T, Dustrude, T M, Largent-Milnes, T W, Vanderah, M, Khanna, R, Khanna   +5 more
openaire   +2 more sources

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Liz, Márcia A., Mar, Fernando M., Marques, Ana M., Morgado, Marlene M., Pemble, Hayley, Pimentel, Helena I., Santos, Telma E., Sousa, Mónica M., Sousa, Vera F., Sutherland, Calum, Vieira, Sílvia, Wittmann, Torsten, Woodgett, James R.   +12 more
core   +16 more sources

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease

Cells, 2021
Mitochondrial morphology and motility (mitochondrial dynamics) play a major role in the proper functioning of distant synapses. In Huntington’s disease (HD), mitochondria become fragmented and less motile, but the mechanisms leading to these changes are ...
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +1 more source

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission [PDF]

Molecular Neurobiology, 2018
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states.
Jie Yu, Aubin Moutal, Angie Dorame, Shreya S. Bellampalli, Aude Chefdeville, Iori Kanazawa, Nancy Y. N. Pham, Ki Duk Park, Jill M. Weimer, Rajesh Khanna   +9 more
openaire   +2 more sources

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation [PDF]

Molecular Neurobiology, 2017
Glioblastoma (GBM) is an aggressive primary brain tumor. The rapid growth and the privileged provenance of the tumor within the brain contribute to its aggressivity and poor therapeutic targeting. A poor prognostic factor in glioblastoma is the deletion or mutation of the Nf1 gene.
Aubin Moutal, Lex Salas Villa, Seul Ki Yeon, Kyle T. Householder, Ki Duk Park, Rachael W. Sirianni, Rajesh Khanna   +6 more
openaire   +2 more sources

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking [PDF]

Journal of Biological Chemistry, 2013
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and protein-protein interactions have been posited as NaV-trafficking mechanisms. Here, we tested if modification of the axonal collapsin response mediator protein 2 (CRMP2) by a small ubiquitin-like modifier ...
Erik T, Dustrude, Sarah M, Wilson, Weina, Ju, Yucheng, Xiao, Rajesh, Khanna   +4 more
openaire   +2 more sources

Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity

Cells, 2022
Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive.
Yih-Hsin Chang, Hui-Ju Yang, Huan-Wen Chen, Chiao-Wan Hsiao, Yi-Chen Hsieh, Yu-Wei Chan, Shu-Wen Chang, Wei-Lun Hwang, Wei-Shone Chen, Hou-Hsuan Cheng, Teh-Ying Chou, Fu-Pang Chang, Hsiang-Ling Ho, Fang-Yeh Chu, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau   +17 more
doaj   +1 more source

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceThe voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the membrane is required for function of NaV1.7. However, the mechanisms determining how NaV1.7 is trafficked to neuronal cell membranes are poorly understood. Here, we elucidate a signaling program involving a complex and intriguing
Erik T. Dustrude, Aubin Moutal, Xiaofang Yang, Yuying Wang, May Khanna, Rajesh Khanna   +5 more
openaire   +2 more sources

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation [PDF]

Journal of Biological Chemistry, 2008
Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons. This action is regulated by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3) at sites that are hyperphosphorylated in Alzheimer disease.
Cole, Adam R., Soutar, Marc P. M., Rembutsu, Makoto, van Aalten, Lidy, Hastie, C. James, Mclauchlan, Hilary, Peggie, Mark, Balastik, Martin, Lu, Kun Ping, Sutherland, Calum   +9 more
openaire   +3 more sources

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2 [PDF]

The Journal of Neuroscience, 2010
Protein phosphatase 2A (PP2A) is indispensable in development, and deficits of PP2A and deterioration of neuronal axons have been observed in several neurodegenerative disorders, but the direct link between PP2A and the neuronal axon development is still missing. Here, we show that PP2A is essential for axon development in transfected rat brain and the
Ling-Qiang, Zhu, Hong-Yun, Zheng, Cai-Xia, Peng, Dan, Liu, Hong-Lian, Li, Qun, Wang, Jian-Zhi, Wang   +6 more
openaire   +2 more sources