Results 21 to 30 of about 3,056 (192)

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation [PDF]

Molecular Neurobiology, 2017
Glioblastoma (GBM) is an aggressive primary brain tumor. The rapid growth and the privileged provenance of the tumor within the brain contribute to its aggressivity and poor therapeutic targeting. A poor prognostic factor in glioblastoma is the deletion or mutation of the Nf1 gene.
Aubin Moutal, Lex Salas Villa, Seul Ki Yeon, Kyle T. Householder, Ki Duk Park, Rachael W. Sirianni, Rajesh Khanna   +6 more
openaire   +2 more sources

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking [PDF]

Journal of Biological Chemistry, 2013
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and protein-protein interactions have been posited as NaV-trafficking mechanisms. Here, we tested if modification of the axonal collapsin response mediator protein 2 (CRMP2) by a small ubiquitin-like modifier ...
Erik T, Dustrude, Sarah M, Wilson, Weina, Ju, Yucheng, Xiao, Rajesh, Khanna   +4 more
openaire   +2 more sources

Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity

Cells, 2022
Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive.
Yih-Hsin Chang, Hui-Ju Yang, Huan-Wen Chen, Chiao-Wan Hsiao, Yi-Chen Hsieh, Yu-Wei Chan, Shu-Wen Chang, Wei-Lun Hwang, Wei-Shone Chen, Hou-Hsuan Cheng, Teh-Ying Chou, Fu-Pang Chang, Hsiang-Ling Ho, Fang-Yeh Chu, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau   +17 more
doaj   +1 more source

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceThe voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the membrane is required for function of NaV1.7. However, the mechanisms determining how NaV1.7 is trafficked to neuronal cell membranes are poorly understood. Here, we elucidate a signaling program involving a complex and intriguing
Erik T. Dustrude, Aubin Moutal, Xiaofang Yang, Yuying Wang, May Khanna, Rajesh Khanna   +5 more
openaire   +2 more sources

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation [PDF]

Journal of Biological Chemistry, 2008
Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons. This action is regulated by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3) at sites that are hyperphosphorylated in Alzheimer disease.
Cole, Adam R., Soutar, Marc P. M., Rembutsu, Makoto, van Aalten, Lidy, Hastie, C. James, Mclauchlan, Hilary, Peggie, Mark, Balastik, Martin, Lu, Kun Ping, Sutherland, Calum   +9 more
openaire   +3 more sources

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2 [PDF]

The Journal of Neuroscience, 2010
Protein phosphatase 2A (PP2A) is indispensable in development, and deficits of PP2A and deterioration of neuronal axons have been observed in several neurodegenerative disorders, but the direct link between PP2A and the neuronal axon development is still missing. Here, we show that PP2A is essential for axon development in transfected rat brain and the
Ling-Qiang, Zhu, Hong-Yun, Zheng, Cai-Xia, Peng, Dan, Liu, Hong-Lian, Li, Qun, Wang, Jian-Zhi, Wang   +6 more
openaire   +2 more sources

Identification of Anti-Collapsin Response Mediator Protein 2 Antibodies in Patients With Encephalitis or Encephalomyelitis

Frontiers in Immunology, 2022
Background and PurposeAn increasing number of autoimmune encephalitis (AE)-associated autoantibodies have been successfully characterized. However, many cases of AE remain unexplained on account of unknown antibodies.
Kaibiao Xu, Dongmei Wang, Yan He, Shengnan Wang, Guanghui Liu, Yue Pan, Haishan Jiang, Yu Peng, Fenliang Xiao, Yihua Huang, Qiqi Wang, Yongming Wu, Suyue Pan, Yafang Hu   +13 more
doaj   +1 more source

Structural basis for CRMP2-induced axonal microtubule formation [PDF]

Scientific Reports, 2017
AbstractMicrotubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown.
Shinsuke Niwa, Fumio Nakamura, Yuri Tomabechi, Mari Aoki, Hideki Shigematsu, Takashi Matsumoto, Atsushi Yamagata, Shuya Fukai, Nobutaka Hirokawa, Yoshio Goshima, Mikako Shirouzu, Ryo Nitta   +11 more
openaire   +2 more sources

Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model

Frontiers in Psychiatry, 2020
Current evidence supports the idea that neural plasticity is a potential cause of depression. Abundant studies indicate that CRMP2 has important roles in neural plasticity. Moreover, CRMP2 may contribute to the etiology of depression.
Dan Xiang, Jiawei Xiao, Siqi Sun, Linyan Fu, Lihua Yao, Gaohua Wang, Gaohua Wang, Zhongchun Liu, Zhongchun Liu   +8 more
doaj   +1 more source

Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons

Neurobiology of Pain, 2022
The voltage-gated sodium NaV1.7 channel sets the threshold for electrogenesis. Mutations in the gene encoding human NaV1.7 (SCN9A) cause painful neuropathies or pain insensitivity. In dorsal root ganglion (DRG) neurons, activity and trafficking of NaV1.7
Santiago I. Loya-López, Paz Duran, Dongzhi Ran, Aida Calderon-Rivera, Kimberly Gomez, Aubin Moutal, Rajesh Khanna   +6 more
doaj   +1 more source