Results 31 to 40 of about 3,047 (190)
Structural basis for CRMP2-induced axonal microtubule formation [PDF]
Scientific Reports, 2017 AbstractMicrotubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown.
Shinsuke Niwa +11 more
openaire +2 more sources
Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers [PDF]
, 2013 This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Objective]: This study aims at exploring the effects of sodium tungstate treatment on hypothalamic plasticity, which is known to have an ...
Carmona, María del Carmen +3 more
core +4 more sources
Frontiers in Psychiatry, 2020 Current evidence supports the idea that neural plasticity is a potential cause of depression. Abundant studies indicate that CRMP2 has important roles in neural plasticity. Moreover, CRMP2 may contribute to the etiology of depression.
Dan Xiang +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Background and PurposeAn increasing number of autoimmune encephalitis (AE)-associated autoantibodies have been successfully characterized. However, many cases of AE remain unexplained on account of unknown antibodies.
Kaibiao Xu +13 more
doaj +1 more source
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
Frontiers in Molecular Neuroscience, 2020 The dynamic trafficking of AMPA receptors (AMPARs), which enables the endocytosis, recycling, and exocytosis of AMPARs, is crucial for synaptic plasticity. Endophilin2, which directly interacts with the GluA1 subunit of AMPARs, plays an important role in
Jifeng Zhang +9 more
doaj +1 more source
Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons
Neurobiology of Pain, 2022 The voltage-gated sodium NaV1.7 channel sets the threshold for electrogenesis. Mutations in the gene encoding human NaV1.7 (SCN9A) cause painful neuropathies or pain insensitivity. In dorsal root ganglion (DRG) neurons, activity and trafficking of NaV1.7
Santiago I. Loya-López +6 more
doaj +1 more source
CRMP2 is necessary for Neurofibromatosis type 1 related pain [PDF]
Channels, 2018 Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity ...
Aubin Moutal +4 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2021 Chronic stress appears to alter DNA methylation and DNA methyltransferases (DNMTs) in brain regions related to emotion. Collapsin response mediator protein-2 (CRMP2) mediates the development of depression by regulating microtubule dynamics. In this study,
Dan Xiang +5 more
doaj +1 more source
Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide [PDF]
, 2014 The novel antiepileptic drug lacosamide (LCM; SPM927, Vimpat®) has been heralded as having a dual-mode of action through interactions with both the voltage-gated sodium channel and the neurite outgrowth-promoting collapsin response mediator protein 2 ...
Khanna, Rajesh, Wilson, Sarah M.
core +2 more sources