Results 41 to 50 of about 3,047 (190)

Challenging the catechism of therapeutics for chronic neuropathic pain: targeting CaV2.2 interactions with CRMP2 peptides [PDF]

, 2013
Chronic neuropathic pain management is a worldwide concern. Pharmaceutical companies globally have historically targeted ion channels as the therapeutic catechism with many blockbuster successes.
Feldman, Polina, Khanna, Rajesh
core   +1 more source

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis [PDF]

, 2015
Background Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could ...
A Arif, AK Fu, AK Upadhyay, AR Cole, AR Cole, B Tian, BS Li, C Huang, C Vuaillat, C. James Hastie, Calum Sutherland, CJ Strock, D Tang, D Tang, DJ Giard, DO Morgan, Douglas J. Lamont, DP Hanger, E Contreras-Vallejos, E Oliemuller, E Petsalaki, EC Gilmore, EE Vincent, EF Schmidt, F Causeret, F Plattner, Francis A. Carey, G Feldmann, G Kusakawa, GN Patrick, HS Choi, J Ko, J Lindqvist, J Yuasa-Kawada, J Zhang, JA Bibb, JP Eggers, JY Shih, JY Shih, K Pozo, K Pozo, K Shimada, KY Lee, L Cao, LH Tsai, M Brown, MS Lee, Nicholas A. Morrice, Nicola J. Grant, P Vincent, Philip J. Coates, RY Poon, S Patel, SM Ehrlich, SP Banks-Schlegel, Susan E. Bray, T Chae, T Kimura, T Ohshima, T Ohshima, T Sandal, WQ Fang, WY Fu, X Gao, X Liu, Y Watanabe, YT Kwon, YT Kwon, Yvonne L. Woods, Z Songyang, ZH Cheung   +70 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons [PDF]

Channels, 2013
The axon/dendrite specification collapsin response mediator protein 2 (CRMP2) bidirectionally modulates N-type voltage-gated Ca ( 2+) channels (CaV2.2). Here we demonstrate that small ubiquitin-like modifier (SUMO) protein modifies CRMP2 via the SUMO E2-conjugating enzyme Ubc9 in vivo. Removal of a SUMO conjugation site KMD in CRMP2 (K374A/M375A/D376A;
Weina, Ju, Qi, Li, Sarah M, Wilson, Joel M, Brittain, Louay, Meroueh, Rajesh, Khanna   +5 more
openaire   +2 more sources

Betaine Ameliorates Schizophrenic Traits by Functionally Compensating KIF3-Based CRMP2 Transport [PDF]

SSRN Electronic Journal, 2020
In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but the related molecular mechanism remains largely elusive. Using Kif3b+/- mice as a model with SCZ-like behaviors, we found that a high-betaine diet can significantly alleviate schizophrenic traits related to neuronal morphogenesis and behaviors.
Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Akiyoshi Kakita, Manabu Toyoshima, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa   +11 more
openaire   +3 more sources

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Frontiers in Cellular Neuroscience, 2014
Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy.
Sarah M Wilson, Aubin eMoutal, Ohannes K Melemedjian, Yuying eWang, Weina eJu, Liberty eFrancois-Moutal, May eKhanna, Rajesh eKhanna   +7 more
doaj   +1 more source

SUMOylation and calcium signalling: potential roles in the brain and beyond [PDF]

, 2017
Small ubiquitin-like modi er (SUMO) conjugation (or SUMOylation) is a post-translational protein modi cation implicated in alterations to protein expression, localization and func- tion. Despite a number of nuclear roles for SUMO being well characterized,
Abeywardana, Anderson, Bean, Benson, Bernt, Berridge, Bezprozvanny, Binda, Bonifati, Bourinet, Brawek, Brittain, Broers, Caraci, Cartwright, Chandra, Chandra, Chang, Cho, Cimarosti, Cimarosti, Cizkova, Clapham, Craig, Cuomo, Dai, Dai, Davila, Deng, Di-Bacco, Dib-Hajj, Dolmetsch, Dorval, Dorval, Doyle, Dustrude, Dutting, Eckermann, Es-Salah-Lamoureux, Feliciangeli, Feligioni, Felix, Flavell, Flotho, Gareau, Geoffroy, Girach, Golbe, Gong, Gong, Guerra de Souza, Guo, Guo, Gupta, Haass, Hagiwara, Hang, Harris, Hay, Hendriks, Hendriks, Henley, Hermann, Hickey, Hietakangas, Jagodic, Janer, Jardin, Johnson, Ju, Kaeser, Kang, Kho, Kho, Kim, Kim, Kolli, Konopacki, Krumova, Kruse, Lee, Lee, Lee, Li, Liang, Lima, Lisman, Long, Loriol, Loriol, Lory, Maejima, Marger, Maroteaux, Martin, Matsuzaki, Matsuzaki, McMillan, Melchior, Mendler, Meyer, Mezler, Miljanich, Molinaro, Müller, Nacerddine, Nayak, Nistico, Nowycky, Oh, Oh, Oliveira, Pal, Plant, Plant, Plant, Putzier, Qi, Rajan, Rauck, Rcom-H’cheo-Gauthier, Reverter, Riquelme, Rodriguez, Ronzitti, Rougier, Rush, Sampson, Sarge, Schorova, Schäfer, Selkoe, Shalizi, Shen, Shinbo, Silveirinha, Sinha, Smith, Sozen, Stapels, Steinlein, Surmeier, Südhof, Taira, Tanabe, Tang, Thornton, Um, Walsh, Wang, Wang, Wang, Wang, Wang, Waxman, Weingarten, Wheeler, Wheeler, Wilkins, Wilson, Wong, Wong, Woodcock, Xu, Xu, Yang, Yun, Zamponi, Zamponi, Zhang, Zhang, Zhang, Zhao, Zhu, Zhuchenko, Zunino, Zündorf   +176 more
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GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout [PDF]

Communications Biology, 2019
AbstractKnockout of phosphatase and tensin homolog (PTEN−/−) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demonstrate that PTEN−/− also abrogates the inhibitory activity of GSK3 on collapsin response mediator protein 2 ...
Marco Leibinger, Alexander M. Hilla, Anastasia Andreadaki, Dietmar Fischer   +3 more
openaire   +2 more sources

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

Neurobiology of Pain, 2019
Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels.
Aubin Moutal, Shizhen Luo, Tally M. Largent-Milnes, Todd W. Vanderah, Rajesh Khanna   +4 more
doaj   +1 more source

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels [PDF]

Channels, 2018
Drug discovery campaigns directly targeting the voltage-gated sodium channel NaV1.7, a highly prized target in chronic pain, have not yet been clinically successful. In a differentiated approach, we demonstrated allosteric control of trafficking and activity of NaV1.7 by prevention of SUMOylation of collapsin response mediator protein 2 (CRMP2). Spinal
Liberty François-Moutal, David Donald Scott, Samantha Perez-Miller, Vijay Gokhale, May Khanna, Rajesh Khanna   +5 more
openaire   +2 more sources