Results 41 to 50 of about 3,056 (192)

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons [PDF]

Channels, 2013
The axon/dendrite specification collapsin response mediator protein 2 (CRMP2) bidirectionally modulates N-type voltage-gated Ca ( 2+) channels (CaV2.2). Here we demonstrate that small ubiquitin-like modifier (SUMO) protein modifies CRMP2 via the SUMO E2-conjugating enzyme Ubc9 in vivo. Removal of a SUMO conjugation site KMD in CRMP2 (K374A/M375A/D376A;
Weina, Ju, Qi, Li, Sarah M, Wilson, Joel M, Brittain, Louay, Meroueh, Rajesh, Khanna   +5 more
openaire   +2 more sources

Betaine Ameliorates Schizophrenic Traits by Functionally Compensating KIF3-Based CRMP2 Transport [PDF]

SSRN Electronic Journal, 2020
In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but the related molecular mechanism remains largely elusive. Using Kif3b+/- mice as a model with SCZ-like behaviors, we found that a high-betaine diet can significantly alleviate schizophrenic traits related to neuronal morphogenesis and behaviors.
Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Akiyoshi Kakita, Manabu Toyoshima, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa   +11 more
openaire   +3 more sources

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

Neurobiology of Pain, 2019
Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels.
Aubin Moutal, Shizhen Luo, Tally M. Largent-Milnes, Todd W. Vanderah, Rajesh Khanna   +4 more
doaj   +1 more source

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis [PDF]

, 2015
Background Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could ...
A Arif, AK Fu, AK Upadhyay, AR Cole, AR Cole, B Tian, BS Li, C Huang, C Vuaillat, C. James Hastie, Calum Sutherland, CJ Strock, D Tang, D Tang, DJ Giard, DO Morgan, Douglas J. Lamont, DP Hanger, E Contreras-Vallejos, E Oliemuller, E Petsalaki, EC Gilmore, EE Vincent, EF Schmidt, F Causeret, F Plattner, Francis A. Carey, G Feldmann, G Kusakawa, GN Patrick, HS Choi, J Ko, J Lindqvist, J Yuasa-Kawada, J Zhang, JA Bibb, JP Eggers, JY Shih, JY Shih, K Pozo, K Pozo, K Shimada, KY Lee, L Cao, LH Tsai, M Brown, MS Lee, Nicholas A. Morrice, Nicola J. Grant, P Vincent, Philip J. Coates, RY Poon, S Patel, SM Ehrlich, SP Banks-Schlegel, Susan E. Bray, T Chae, T Kimura, T Ohshima, T Ohshima, T Sandal, WQ Fang, WY Fu, X Gao, X Liu, Y Watanabe, YT Kwon, YT Kwon, Yvonne L. Woods, Z Songyang, ZH Cheung   +70 more
core   +3 more sources

GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout [PDF]

Communications Biology, 2019
AbstractKnockout of phosphatase and tensin homolog (PTEN−/−) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demonstrate that PTEN−/− also abrogates the inhibitory activity of GSK3 on collapsin response mediator protein 2 ...
Marco Leibinger, Alexander M. Hilla, Anastasia Andreadaki, Dietmar Fischer   +3 more
openaire   +2 more sources

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels [PDF]

Channels, 2018
Drug discovery campaigns directly targeting the voltage-gated sodium channel NaV1.7, a highly prized target in chronic pain, have not yet been clinically successful. In a differentiated approach, we demonstrated allosteric control of trafficking and activity of NaV1.7 by prevention of SUMOylation of collapsin response mediator protein 2 (CRMP2). Spinal
Liberty François-Moutal, David Donald Scott, Samantha Perez-Miller, Vijay Gokhale, May Khanna, Rajesh Khanna   +5 more
openaire   +2 more sources

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

Neural Plasticity, 2015
Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo   +7 more
doaj   +1 more source

TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex. [PDF]

, 2012
Endocytic trafficking of membrane proteins is essential for neuronal structure and function. We show that Transient Axonal Glycoprotein 1 (TAG1 or CNTN2), a contactin-related adhesion molecule, plays a central role in the differential trafficking of ...
Dang, P., Furley, A. J., Smythe, E.
core   +1 more source

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

Channels, 2022
The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target.
Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna   +4 more
doaj   +1 more source