Results 51 to 60 of about 3,056 (192)

CRMP2–Neurofibromin Interface Drives NF1-related Pain

Neuroscience, 2018
An understudied symptom of the genetic disorder Neurofibromatosis type 1 (NF1) is chronic idiopathic pain. We used targeted editing of Nf1 in rats to provide direct evidence of a causal relationship between neurofibromin, the protein product of the Nf1 gene, and pain responses.
Aubin, Moutal, Li, Sun, Xiaofang, Yang, Wennan, Li, Song, Cai, Shizhen, Luo, Rajesh, Khanna   +6 more
openaire   +3 more sources

Calcium channel modulation as a target in chronic pain control [PDF]

, 2017
Neuropathic pain remains poorly treated for large numbers of patients and little progress has been made in developing novel classes of analgesics. To redress this issue, ziconotide (PrialtTM ) was developed and approved as a first in class synthetic ...
Dickenson, AH, Montagut Bordas, C, Patel, RA   +2 more
core   +1 more source

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Molecular Brain, 2021
Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2).
Kimberly Gomez, Dongzhi Ran, Cynthia L. Madura, Aubin Moutal, Rajesh Khanna   +4 more
doaj   +1 more source

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

Neural Regeneration Research, 2017
Axonal degeneration is a key pathological feature in many neurological diseases. It often leads to persistent deficits due to the inability of axons to regenerate in the central nervous system.
Jian-Nan Zhang, Jan C Koch
doaj   +1 more source

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury

Frontiers in Cellular Neuroscience, 2014
Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the ...
Sarah Marie Wilson, Seul eKi Yeon, Xiao-Fang eYang, Ki Duk ePark, Rajesh eKhanna   +4 more
doaj   +1 more source

CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway

Cell Death and Disease, 2022
As the predominant stroma cells of tumor microenvironment (TME), cancer associated fibroblasts (CAFs) are robust tumor player of different malignancies.
Yunfeng Jin, Saiyan Bian, Hui Wang, Jiahang Mo, He Fei, Li Li, Tong Chen, Hua Jiang   +7 more
doaj   +1 more source

Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement

Arthritis Research & Therapy, 2022
Background Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsatisfactory.
Yue-Peng Jiang, Song Wang, Wei-Dong Lai, Xue-Qing Wu, Yan Jin, Zheng-Hao Xu, Aubin Moutal, Rajesh Khanna, Ki Duk Park, Zhi-Ming Shan, Cheng-Ping Wen, Jie Yu   +11 more
doaj   +1 more source

Perinatale Hirnschäden und Neuroprotektion [PDF]

, 2018
Perinatal brain damage is a main factor for mortality and long-term morbidity in infants. Several mechanisms have been identified which can lead to perinatal brain injury, such as alterations of oxygen pressure, pharmaceuticals, drugs of abuse, and ...
Koppelstätter, Andrea
core   +1 more source

In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum [PDF]

, 2015
The Maurer’s clefts (MCs) are very important for the survival of Plasmodium falciparum within an infected cell as they are induced by the parasite itself in the erythrocyte for protein trafficking.
Adebiyi, Ezekiel, Brors, B., Isewon, Itunuoluwa, Oyelade, O. J.   +3 more
core   +6 more sources