Results 51 to 60 of about 3,047 (190)

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

Neural Plasticity, 2015
Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo   +7 more
doaj   +1 more source

TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex. [PDF]

, 2012
Endocytic trafficking of membrane proteins is essential for neuronal structure and function. We show that Transient Axonal Glycoprotein 1 (TAG1 or CNTN2), a contactin-related adhesion molecule, plays a central role in the differential trafficking of ...
Dang, P., Furley, A. J., Smythe, E.
core   +1 more source

CRMP2–Neurofibromin Interface Drives NF1-related Pain

Neuroscience, 2018
An understudied symptom of the genetic disorder Neurofibromatosis type 1 (NF1) is chronic idiopathic pain. We used targeted editing of Nf1 in rats to provide direct evidence of a causal relationship between neurofibromin, the protein product of the Nf1 gene, and pain responses.
Aubin, Moutal, Li, Sun, Xiaofang, Yang, Wennan, Li, Song, Cai, Shizhen, Luo, Rajesh, Khanna   +6 more
openaire   +3 more sources

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

Channels, 2022
The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target.
Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna   +4 more
doaj   +1 more source

Calcium channel modulation as a target in chronic pain control [PDF]

, 2017
Neuropathic pain remains poorly treated for large numbers of patients and little progress has been made in developing novel classes of analgesics. To redress this issue, ziconotide (PrialtTM ) was developed and approved as a first in class synthetic ...
Dickenson, AH, Montagut Bordas, C, Patel, RA   +2 more
core   +1 more source

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

Neural Regeneration Research, 2017
Axonal degeneration is a key pathological feature in many neurological diseases. It often leads to persistent deficits due to the inability of axons to regenerate in the central nervous system.
Jian-Nan Zhang, Jan C Koch
doaj   +1 more source

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Molecular Brain, 2021
Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2).
Kimberly Gomez, Dongzhi Ran, Cynthia L. Madura, Aubin Moutal, Rajesh Khanna   +4 more
doaj   +1 more source

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway

Cell Death and Disease, 2022
As the predominant stroma cells of tumor microenvironment (TME), cancer associated fibroblasts (CAFs) are robust tumor player of different malignancies.
Yunfeng Jin, Saiyan Bian, Hui Wang, Jiahang Mo, He Fei, Li Li, Tong Chen, Hua Jiang   +7 more
doaj   +1 more source