Results 61 to 70 of about 3,047 (190)
Perinatale Hirnschäden und Neuroprotektion [PDF]
, 2018 Perinatal brain damage is a main factor for mortality and long-term morbidity in infants. Several mechanisms have been identified which can lead to perinatal brain injury, such as alterations of oxygen pressure, pharmaceuticals, drugs of abuse, and ...
Koppelstätter, Andrea
core +1 more source
Frontiers in Cellular Neuroscience, 2014 Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the ...
Sarah Marie Wilson +4 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsatisfactory.
Yue-Peng Jiang +11 more
doaj +1 more source
Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks [PDF]
, 2009 The mammalian postsynaptic density (PSD) comprises a complex collection of ~1100 proteins. Despite extensive knowledge of individual proteins, the overall organization of the PSD is poorly understood.
Choudhary, Jyoti S +8 more
core +1 more source
Characterization of A Novel Autoimmune Encephalitis Associated Antibody against CRMP2 [PDF]
, 2021 ABSTRACTObjectiveAutoimmune encephalitis (AE) is a large category disorder urging antibody characterization. The aim was to identify a novel AE related autoantibody targeting an intracellular synaptic protein.MethodsSuspected AE patients had negative conventional antibodies screening but strong immunolabel signals on rat brain sections with the serum ...
Kaibiao Xu +13 more
openaire +1 more source
In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum [PDF]
, 2015 The Maurer’s clefts (MCs) are very important for the survival of Plasmodium falciparum within an infected cell as they are induced by the parasite itself in the erythrocyte for protein trafficking.
Adebiyi, Ezekiel +3 more
core +6 more sources
Genomics of lithium action and response [PDF]
, 2017 Lithium is the most successful mood stabiliser treatment for bipolar disorder. However, unlike conventional drugs that are designed to interact with a specific molecular target, the actions of lithium are distributed across many biological processes and ...
Pickard, Benjamin S.
core +1 more source
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function [PDF]
Channels, 2017 The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes for CRMP2 interaction with, and trafficking of ...
Erik Thomas Dustrude +5 more
openaire +2 more sources
CRMP2 Tethers Kainate Receptor Activity to Cytoskeleton Dynamics during Neuronal Maturation [PDF]
The Journal of Neuroscience, 2013 The CRMP2 and CRMP4 proteins are strongly expressed in the developing nervous system, mediating neurite outgrowth, neuronal polarity, and axon guidance. In the present study, we demonstrate the interaction of the CRMP2 and CRMP4 proteins with the GluK5 subunit of the kainate (KA) receptor (KAR) and investigated the role of KARs in modulating the ...
Joana M, Marques +7 more
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PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells [PDF]
Molecular Neurobiology, 2020 AbstractThe signalling protein PKCγ is a major regulator of Purkinje cell development and synaptic function. We have shown previously that increased PKCγ activity impairs dendritic development of cerebellar Purkinje cells. Mutations in the protein kinase Cγ gene (PRKCG) cause spinocerebellar ataxia type 14 (SCA14).
Sabine C. Winkler +2 more
openaire +2 more sources