Results 61 to 70 of about 3,056 (192)
Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks [PDF]
, 2009 The mammalian postsynaptic density (PSD) comprises a complex collection of ~1100 proteins. Despite extensive knowledge of individual proteins, the overall organization of the PSD is poorly understood.
Choudhary, Jyoti S +8 more
core +1 more source
Characterization of A Novel Autoimmune Encephalitis Associated Antibody against CRMP2 [PDF]
, 2021 ABSTRACTObjectiveAutoimmune encephalitis (AE) is a large category disorder urging antibody characterization. The aim was to identify a novel AE related autoantibody targeting an intracellular synaptic protein.MethodsSuspected AE patients had negative conventional antibodies screening but strong immunolabel signals on rat brain sections with the serum ...
Kaibiao Xu +13 more
openaire +1 more source
Genomics of lithium action and response [PDF]
, 2017 Lithium is the most successful mood stabiliser treatment for bipolar disorder. However, unlike conventional drugs that are designed to interact with a specific molecular target, the actions of lithium are distributed across many biological processes and ...
Pickard, Benjamin S.
core +1 more source
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice [PDF]
Open Biology, 2019 O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease.
Villo Muha +13 more
doaj +1 more source
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function [PDF]
Channels, 2017 The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes for CRMP2 interaction with, and trafficking of ...
Erik Thomas Dustrude +5 more
openaire +2 more sources
Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons [PDF]
, 2013 A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties.
Hartl, Daniela +6 more
core +6 more sources
CRMP2 Tethers Kainate Receptor Activity to Cytoskeleton Dynamics during Neuronal Maturation [PDF]
The Journal of Neuroscience, 2013 The CRMP2 and CRMP4 proteins are strongly expressed in the developing nervous system, mediating neurite outgrowth, neuronal polarity, and axon guidance. In the present study, we demonstrate the interaction of the CRMP2 and CRMP4 proteins with the GluK5 subunit of the kainate (KA) receptor (KAR) and investigated the role of KARs in modulating the ...
Joana M, Marques +7 more
openaire +2 more sources
PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells [PDF]
Molecular Neurobiology, 2020 AbstractThe signalling protein PKCγ is a major regulator of Purkinje cell development and synaptic function. We have shown previously that increased PKCγ activity impairs dendritic development of cerebellar Purkinje cells. Mutations in the protein kinase Cγ gene (PRKCG) cause spinocerebellar ataxia type 14 (SCA14).
Sabine C. Winkler +2 more
openaire +2 more sources
ASN Neuro, 2019 We previously showed that treatment with lanthionine ketimine ethyl ester (LKE) reduced disease severity and axonal damage in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and increased neuronal maturation and ...
Aubin Moutal +10 more
doaj +1 more source
Otsides nõela heinakuhjast – endometrioosi biomarkerid [PDF]
, 2017 Endometrioosi diagnoosimiseks puuduvad siiani mitteinvasiivsed ja minimaalselt invasiivsed biomarkerid ning haiguse diagnoos põhineb peamiselt laparoskoopilisel operatsioonil ja endometrioosikollete histoloogilisel uuringul.
Anderson, Kristi +4 more
core +2 more sources