Results 71 to 80 of about 3,047 (190)
ASN Neuro, 2019 We previously showed that treatment with lanthionine ketimine ethyl ester (LKE) reduced disease severity and axonal damage in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and increased neuronal maturation and ...
Aubin Moutal +10 more
doaj +1 more source
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice [PDF]
Open Biology, 2019 O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease.
Villo Muha +13 more
doaj +1 more source
First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia [PDF]
, 2010 Background: The pathogenesis of HIV-associated dementia (HAD) is poorly understood. To date, detailed proteomic fingerprinting directly from autopsied brain tissues of HAD and HIV non-dementia patients has not been performed.
Zhou, Li +11 more
core +2 more sources
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Otsides nõela heinakuhjast – endometrioosi biomarkerid [PDF]
, 2017 Endometrioosi diagnoosimiseks puuduvad siiani mitteinvasiivsed ja minimaalselt invasiivsed biomarkerid ning haiguse diagnoos põhineb peamiselt laparoskoopilisel operatsioonil ja endometrioosikollete histoloogilisel uuringul.
Anderson, Kristi +4 more
core +2 more sources
Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology
Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini +1 more
wiley +1 more source
Scientific Reports, 2017 The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during development, tissue homeostasis and interactions between tumours and stroma.
Adil R. Sarhan +6 more
doaj +1 more source
Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons [PDF]
, 2013 A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties.
Hartl, Daniela +6 more
core +6 more sources
Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors [PDF]
Pain, 2017 AbstractNeurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or a homozygous deletion of theNf1gene, is characterized by tumorigenesis, cognitive dysfunction, seizures, migraine, and pain. Omic studies on human NF1 tissues identified an increase in the expression of collapsin response mediator protein 2 (CRMP2), a ...
Moutal, Aubin +13 more
openaire +2 more sources
Chinese Medical Journal, 2017 Background: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury. We determined whether CRMP2 modulates ischemic injury in the retinal of Ocular ischemic syndrome (OIS). This study was to explore the
Yu Wang +4 more
doaj +1 more source