Results 81 to 90 of about 3,056 (192)

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain [PDF]

Neuronal Signaling, 2018
Neuropathic pain represents a significant and mounting burden on patients and society at large. Management of neuropathic pain, however, is both intricate and challenging, exacerbated by the limited quantity and quality of clinically available treatments. On this stage, dysfunctional voltage-gated ion channels, especially the presynaptic N-type voltage-
Chew, Lindsey A., Khanna, Rajesh
openaire   +2 more sources

Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen [PDF]

, 2014
Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The tissue damage characteristic of BU lesions is known to be driven by the secretion of the potent lipidic exotoxin mycolactone.
A Andreoli, A Mve-Obiang, AA Pahlevan, AG Fraga, Alexandra G. Fraga, AU Luthi, B Belletti, B Ravikumar, Belém Sampaio-Marques, BS Hall, BW Bernstein, C Fung, D Meiri, DE Ellen, DH Connor, DH Connor, DJ Klionsky, DJ Klionsky, DP Berry, DS Snyder, E Coutanceau, E Marion, E Torrado, E Torrado, E Torrado, EF Schmidt, F Nackers, F Portaels, Fernanda Proença, FS Sarfo, H Hong, HP Ehrlich, HP Ehrlich, I Tanida, J Guarner, JK Clancey, JL Webb, Jorge Pedrosa, José B. Gama, K Kibadi, KM George, KM George, KM George, L Gong, L Guenin-Mace, L Marsollier, L Marsollier, L Marsollier, M Songane, M Yamauchi, Manuel T. Silva, Maria A. Carvalho, MS Oliveira, MT Silva, OG Dodge, P MacCallum, Pamela L. C. Small, Paula Ludovico, R Sumpter Jr, RW Merritt, S Adusumilli, S Buktenica, S Ohlmeier, SM Krane, Steffen Ohlmeier, Teresa G. Martins, TP Stinear, TY Quek, V Deretic, VI Korolchuk, VJ Allan   +70 more
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Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, Volume 603, Issue 15, Page 4237-4253, 1 August 2025.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

Molecular Neurobiology, 2019
Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed, homologous phosphoproteins best known for coordinating cytoskeletal formation and regulating cellular division, migration, polarity, and synaptic connection. CRMP2, the most studied of the five family members, is best known for its affinity for tubulin heterodimers and
Aubin Moutal, Katherine A. White, Aude Chefdeville, Rachel N. Laufmann, Peter F. Vitiello, Douglas Feinstein, Jill M. Weimer, Rajesh Khanna   +7 more
openaire   +3 more sources

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. [PDF]

, 2015
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke of the action potential (AP).
Abdulla, Abrahamsen, Abriel, Abriel, Abriel, Abriel, Akopian, Akopian, Akopian, Aley, Aley, Amaya, Arévalo, Bair, Basbaum, Battaini, Ben-Johny, Bendahhou, Beneski, Bennett, Bennett, Berta, Bierhaus, Bierhaus, Bird, Bird, Biswas, Black, Black, Black, Bongiorno, Bouhassira, Bretin, Brouwer, Brower, Brüggemann, Cachemaille, Campbell, Cang, Cantrell, Cantrell, Casals-Diaz, Catterall, Catterall, Cesare, Cesare, Chahine, Chatelier, Chattopadhyay, Chen, Chen, Cheng, Chi, Ciechanover, Coggeshall, Cohen, Costa, Costa, Coward, Coward, Cox, Cronin, Cummins, Cummins, Cummins, Cusdin, Daemen, Dascal, Decosterd, Deribe, Deschênes, Deval, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dietrich, Dina, Dina, Djouhri, Dogrul, Dong, Duan, Dubin, Dustrude, Edinger, Ednie, England, Errington, Errington, Faber, Faber, Fahmi, Ferrari, Ferreira, Ferreira, Fertleman, Firsov, Fitzgerald, Fjell, Fotia, Fotia, Fukuoka, Fukuoka, Galan, Gasser, Gaudet, Gee, Gershon, Gold, Gold, Gold, Goldin, Gould, Gudes, Han, Heikamp, Henry, Herzog, Herzog, Hirade, Hiruma, Ho, Hockley, Hoeijmakers, Hoeijmakers, Huang, Hucho, Hudmon, Hunter, Ikeda, Inagaki, Isom, Isom, Isom, James, Jarecki, Jarvis, Ji, Ji, Jin, Joazeiro, Johnson, Johnson, Joshi, Julius, Kazarinova-Noyes, Kazen-Gillespie, Kerr, Khasar, Khasar, Khasar, Kim, Kispersky, Klugbauer, Kreegipuu, Kresge, Kress, Kretschmer, Kruger, Laedermann, Laedermann, Laedermann, Laedermann, Lai, Latremoliere, Leipold, Leo, Leung, Li, Liang, Liu, Liu, Liu, Liu, Liu, Lolignier, Lopez-Santiago, Lopez-Santiago, Lou, Luo, Luo, Maingret, Malhotra, Malhotra, Maltsev, Mann, Mao, Matzner, Matzner, Messner, Metzger, Millan, Minett, Mittmann, Moon, Moremen, Morgan, Mori, Murphy, Murray, Nagasako, Narayanan, Nassar, Nelson, Noda, Novella, Numann, Nuss, Obata, Olsson, Payandeh, Perry, Persson, Pertin, Petho, Pickart, Pierre, Pitchford, Plummer, Priest, Qu, Rang, Ranscht, Raymond, Recio-Pinto, Ren, Renganathan, Renganathan, Ritchie, Rossie, Rossier, Rush, Rush, Rush, Sadamasu, Sangameswaran, Sanna, Schaller, Schepelmann, Schild, Schirmeyer, Schmidt, Schmidt, Scholz, Shah, Shao, Shi, Shih, Smith, Smith, Snyder, Snyder, Solà, Souza, Stamboulian, Staub, Strickland, Stucky, Sun, Suter, Taiwo, Tan, Thakor, Theriault, Thornalley, Toledo-Aral, Toledo-Aral, Tong, Toth, Turk, Tyrrell, van Bemmelen, Vanoye, Vijayaragavan, Vijayaragavan, Vijayaragavan, von Hehn, Wada, Wada, Waechter, Wang, Waxman, Waxman, Waxman, Waxman, Way, Wells, Widmann, Woolf, Woolf, Woolf, Woolf, Woolf, Wu, Xu, Xu, Xu, Xu, Yan, Yanagita, Yanagita, Yang, Yeomans, Yin, Young, Yu, Yu, Yuhi, Zhang, Zhang, Zhang, Zhang, Zhou, Zhou, Zhuang, Zimmer, Zochodne   +318 more
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Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory

Human Brain Mapping, Volume 46, Issue 10, July 2025.
This study highlights the strong correlation between functional language lateralization and gray matter structure, revealing how hemispheric asymmetries in language influence memory organization. Targeted language laterality indices (LIs) provide effective discrimination between temporal lobe epilepsy patients and matched healthy participants, with the
Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy   +5 more
wiley   +1 more source

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

Molecular Neurodegeneration, 2011
Background Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain.
Rockenstein Edward, Achim Cristian L, Trejo-Morales Margarita, Dumaop Wilmar, Patrick Christina, Ruf Rebecca, Crews Leslie, Masliah Eliezer   +7 more
doaj   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source

Structural Insights into the Altering Function of CRMP2 by Phosphorylation

Cell Structure and Function, 2018
Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity by controlling microtubule dynamics. CRMP2 activity is regulated by semaphorin-induced phosphorylation at the C-terminal tail domain. Unphosphorylated CRMP2 induces effective axonal microtubule formation to give the axonal characteristics to a neurite, whereas phosphorylated ...
Sumi, Takuya, Imasaki, Tsuyoshi, Aoki, Mari, Sakai, Naoki, Nitta, Eriko, Shirouzu, Mikako, Nitta, Ryo   +6 more
openaire   +3 more sources

Epigallocatechin-3-gallate alleviates gestational stress-induced postpartum anxiety and depression-like behaviors in mice by downregulating semaphorin3A and promoting GSK3β phosphorylation in the hippocampus

Frontiers in Molecular Neuroscience, 2023
IntroductionPostpartum depression (PPD) is a common neuropsychiatric disorder characterized by depression and comorbid anxiety during the postpartum period. PPD is difficult to treat because of its elusive mechanisms. Epigallocatechin-3-gallate (EGCG), a
Fang Xu, Hui Wu, Linghua Xie, Qing Chen, Qi Xu, Lihong Sun, Hua Li, Jiaqian Xie, Xinzhong Chen   +8 more
doaj   +1 more source