Results 51 to 60 of about 639 (123)

Short‐Term, Cycle‐Synchronized Adjunctive Therapy With Crocus Total Glucosides Tablets for Cardiac Protection Against Cancer Therapy‐Related Cardiac Dysfunction in Breast Cancer Patients: A Randomized, Double‐Blind, Placebo‐Controlled Trial

MedComm, Volume 7, Issue 6, June 2026.
Cycle‐synchronized CTGT therapy attenuates LVGLS decline and reduces CTRCD in breast cancer patients. This randomized, double‐blind, placebo‐controlled trial assessed whether cycle‐synchronized CTGT prevent CTRCD in 120 breast cancer patients receiving chemotherapy.
Xiaoling Liu, Mengmeng Li, Wenwen Song, Yu Zhang, Wuyun Bao, Chaoyu Liu, Yuan Zhang, Quande Liu, Cheng Zhang, Yun Zhang, Li Li, Mei Zhang   +11 more
wiley   +1 more source

Virtual Screening of Traditional Chinese Medicine Natural Product Inhibitors Targeting AQP1 for Bladder Cancer

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Bladder cancer (BCa) is the most common and representative type of adult urinary tract urothelial cancer, characterized by high incidence and mortality rates. It has become a major disease threatening public health, highlighting the urgent need for the development of comprehensive treatment strategies, including traditional Chinese ...
Di Liu, Qing‐Yu Zhang
wiley   +1 more source

Quality traits of saffron (Crocus sativus L.) produced in the Italian Alps

Open Agriculture, 2017
Saffron (Crocus sativus L.) is a perennial herbaceous geophyte in the Iridaceae family. It propagates vegetatively by corm. All saffron production processes are generally conducted by hand: from bulb implantation, harvesting of flowers to stigma ...
Giorgi Annamaria, Pentimalli Daniela, Giupponi Luca, Panseri Sara   +3 more
doaj   +1 more source

Tandem gene duplications drive divergent evolution of caffeine and crocin biosynthetic pathways in plants

BMC Biology, 2020
Background Plants have evolved a panoply of specialized metabolites that increase their environmental fitness. Two examples are caffeine, a purine psychotropic alkaloid, and crocins, a group of glycosylated apocarotenoid pigments.
Zhichao Xu, Xiangdong Pu, Ranran Gao, Olivia Costantina Demurtas, Steven J. Fleck, Michaela Richter, Chunnian He, Aijia Ji, Wei Sun, Jianqiang Kong, Kaizhi Hu, Fengming Ren, Jiejie Song, Zhe Wang, Ting Gao, Chao Xiong, Haoying Yu, Tianyi Xin, Victor A. Albert, Giovanni Giuliano, Shilin Chen, Jingyuan Song   +21 more
doaj   +1 more source

Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Amal Elrherabi, Oussama Khibech, Mohamed Bouhrim, Abdelouahid Laftouhi, Abdelaaty A. Shahat, Abdullah R. Alanzi, Rashed N. Herqash, Joe Miantezila Basilua, Mohamed Bnouham   +8 more
wiley   +1 more source

Affron® and increase in positive mood: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

EFSA Journal, 2021
Following an application from Pharmactive Biotech Products, S.L. submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Spain, the EFSA Panel on Nutrition, Novel Foods and ...
EFSA Panel on Nutrition, Novel foods and Food allergens (NDA), Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Frank Thies, Sophia Tsabouri, Marco Vinceti, Jean‐Louis Bresson, Alfonso Siani   +17 more
doaj   +1 more source

Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab, Mahdie Hajimonfarednejad, Seyede Maryam Najibi, Mohammad Hashem Hashempur   +3 more
wiley   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, Volume 4, Issue 2, Page 327-342, April 2026.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Saffron Alters Microbial Amino Acid Metabolism and Neurotransmitter Production in a Defined Gut Consortium

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical representation of the metabolic pathways modulated by saffron within defined microbial communities. In the tryptophan pathway, saffron decreased levels of tryptophan and anthranilic acid while increasing concentrations of indole‐3‐acetic acid and tryptamine.
Adelaide E. Horvath, Makenna Grozis, Paul R. S. Baker, Santosh Kapil Kumar Gorti, Robert Proos, Ahmad Imran, Hassan Brim, Thomas D. Horvath, Melinda A. Engevik, Hassan Ashktorab   +9 more
wiley   +1 more source

Crocin Supplementation Mitigates DSS‐Induced Ulcerative Colitis by Promoting Autophagy and Modulating Gut Microbiota in Mice

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Crocin enhanced intestinal barrier integrity and alleviated colonic inflammation in DSS‐induced UC mice. Crocin promoted autophagy by targeting the AMPK/mTOR pathway. Crocin reshaped gut microbiota composition of UC mice. ABSTRACT Crocin has been widely recognized for its anti‐inflammatory and antioxidant properties.
Jiaoyang Xu, Xiaoyu Han, Zizheng Nie, Qinglong Cao, Mu Zhang, Yingying Liu, Chenyang Wu, Jun Yang, Shufen Han   +8 more
wiley   +1 more source