Results 61 to 70 of about 639 (123)

An Updated Review on the Neuroprotective Constituents of Genus Gardenia [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Central Nervous System (CNS) disorders include many diseases with different symptoms and causes. According to the American Psychiatric Association (APA), these disorders are classified into several categories according to the disease‘s etiology and ...
Mohga A. Zedan , Nada M. Mostafa, Fadia S. Youssef , Omayma A. Eldahshan   +3 more
doaj   +1 more source

Therapeutic Modulation of Inflammatory Signaling via Physalis Peruviana‐Derived Exosomes: A Targeted Effect on IKK/NFκB/STAT1

Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.
Exosomes derived from Physalis peruviana contain various bioactive compounds, such as RNAs, proteins, and secondary metabolites. These exosomes have been shown to contain different types of carotenoids that may have therapeutic properties. Physalis peruviana exosomes are capable of exhibiting anti‐inflammatory effects by influencing the IKK/NFκB/STAT1 ...
Cristian Martínez Fajardo, Lucía Morote, Susana López‐López, Alberto José López Jiménez, Oussama Ahrazem, Lourdes Gómez‐Gómez   +5 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, Volume 48, Issue 2, Page 394-427, April 2026.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis

Scientific Reports, 2018
Crocins, the red soluble apocarotenoids of saffron, accumulate in the flowers of Crocus species in a developmental and tissue-specific manner. In Crocus sieberi, crocins accumulate in stigmas but also in a distinct yellow tepal sector, which we ...
Oussama Ahrazem, Javier Argandoña, Alessia Fiore, Carolina Aguado, Rafael Luján, Ángela Rubio-Moraga, Mónica Marro, Cuauhtémoc Araujo-Andrade, Pablo Loza-Alvarez, Gianfranco Diretto, Lourdes Gómez-Gómez   +10 more
doaj   +1 more source

Transcriptome-wide Characterization of Novel WRKY Family Genes Engaged in Crocin Biosynthesis in Crocus sativus

Journal of the American Society for Horticultural Science
Crocins comprise a family of hydrophilic carotenoids with pharmacological properties that are produced in significant quantities in stigma of Crocus sativus.
Guangchun Gao, Jun Li, Ping Wang, Jiming Wu, Jinbiao Xu, Lisa Mao   +5 more
doaj   +1 more source

Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities

Plants
Plants are an important source of essential bioactive compounds that not only have a beneficial role in human health and nutrition but also act as drivers for shaping gut microbiome.
Rakeeb Ahmad Mir, Anshika Tyagi, Sofi Javed Hussain, Mohammed A. Almalki, Mohammad Tarique Zeyad, Rupesh Deshmukh, Sajad Ali   +6 more
doaj   +1 more source

Metabolic engineering of crocins and picrocrocin apocarotenoids in potato group phureja

Engineering Reports
The stigmas of Crocus sativus accumulate the exclusive apocarotenoids crocin and picrocrocin, which are dried and desiccated to make commercial saffron.
Lourdes Gómez‐Gómez, Alberto José López‐Jimenez, Cristian Martinez Fajardo, Lucía Morote, Sarah Frusciante, José Luis Rambla, Gianfranco Diretto, Ángela Rubio‐Moraga, María Mondejar‐López, Enrique Niza, Javier Argandoña, Silvia Presa, Antonio Granell, Oussama Ahrazem   +13 more
doaj   +1 more source

Relationship of Color and Antioxidant Capacity with the Content of Secondary Metabolites in Flowers of Crocosmia

Agronomy
Crocosmia is a genus of bulbous, perennial plants from the Iridaceae family whose characteristic red to orange pigmentation suggests the presence of anthocyanins, flavonoids, and carotenoids—secondary metabolites often associated with antioxidant ...
Manuel Piqueras-García, Cristina Cebrián-Tarancón, Gonzalo L. Alonso, Rosario Sánchez-Gómez   +3 more
doaj   +1 more source

Research Progress in Heterologous Crocin Production. [PDF]

Mar Drugs, 2023
Zhou J, Huang D, Liu C, Hu Z, Li H, Lou S.   +5 more
europepmc   +1 more source