Results 41 to 50 of about 993 (143)

Identification of Compounds of Crocus sativus by GC-MS and HPLC/UV-ESI-MS and Evaluation of Their Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties

Pharmaceuticals, 2023
In order to valorize the species Crocus sativus from Morocco and to prepare new products with high added value that can be used in the food and pharmaceutical industry, our interest was focused on the phytochemical characterization and the biological and
Aziz Drioiche, Atika Ailli, Nadia Handaq, Firdaous Remok, Mohamed Elouardi, Hajar Elouadni, Omkulthom Al Kamaly, Asmaa Saleh, Mohamed Bouhrim, Hanane Elazzouzi, Fadoua El Makhoukhi, Touriya Zair   +11 more
doaj   +1 more source

Crocins ameliorate acute kidney injury in glycerol-induced rhabdomyolysis by targeting the PLIN1/PPARs signaling pathway

Frontiers in Pharmacology
BackgroundRhabdomyolysis (RM) is a potentially life-threatening syndrome characterized by skeletal muscle damage, with acute kidney injury (AKI) being its most severe complication. Currently, no effective treatment exists for RM-induced AKI. Crocins, the
Fangbo Zhang, Yu Li, Qingqing Cai, Ye Zhao, He Xu, Huamin Zhang, Hongjun Yang   +6 more
doaj   +1 more source

Crocins, the active constituents of Crocus Sativus L., counteracted ketamine-induced behavioural deficits in rats

, 2014
Experimental evidence indicates that the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in rodents.
Tarantilis, P. A., Georgiadou, G., Grivas, V., Pitsikas, N.   +3 more
core   +1 more source

Saffron: Chemical Composition and Neuroprotective Activity

Molecules, 2020
Crocus sativus L. belongs to the Iridaceae family and it is commonly known as saffron. The different cultures together with the geoclimatic characteristics of the territory determine a different chemical composition that characterizes the final product ...
Maria Anna Maggi, Silvia Bisti, Cristiana Picco   +2 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The Relation between Drying Conditions and the Development of Volatile Compounds in Saffron (Crocus sativus)

Molecules, 2021
Saffron is derived from the stigmas of the flower Crocus sativus L. The drying process is the most important post-harvest step for converting C. sativus stigmas into saffron.
Teresa Soledad Cid-Pérez, Guadalupe Virginia Nevárez-Moorillón, Carlos Enrique Ochoa-Velasco, Addí Rhode Navarro-Cruz, Paola Hernández-Carranza, Raúl Avila-Sosa   +5 more
doaj   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Use of predictive tools for the analysis of bioactive compounds in Crocus sativus L. flowers

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Crocus sativus L. (saffron) flowers have high bioactive potential because of their content of crocins, safranal and phenolic compounds. The development of predictive models based on near‐infrared (NIR) spectroscopy and partial least squares regression to estimate the antioxidant capacity of saffron flower, evaluated using oxygen ...
Manuel Piqueras‐García, Jorge F Escobar‐Talavera, María Esther Martínez‐Navarro, Gonzalo L Alonso, Rosario Sánchez‐Gómez   +4 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

A New Glycosyltransferase Enzyme from Family 91, UGT91P3, Is Responsible for the Final Glucosylation Step of Crocins in Saffron (Crocus sativus L.)

, 2021
Crocetin is an apocarotenoid formed from the oxidative cleavage of zeaxanthin, by the carotenoid cleavage enzymes CCD2 (in Crocus species) and specific CCD4 enzymes in Buddleja davidii and Gardenia jasminoides.
Sarah Frusciante, Oussama Ahrazem, Gianfranco Diretto, Alberto José López-jimenez, Enrique Niza, Ángela Rubio-Moraga, Lourdes Gómez-Gómez   +6 more
core   +1 more source