Results 171 to 180 of about 519,305 (288)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity. [PDF]

Nat Immunol
Lim KHJ, Schulz O, Lobon I, Castro-Dopico T, Zapata L, Giampazolias E, Frederico B, Castellanos CA, Buck MD, Stainier W, Chakravarty P, Kelly G, Rogers NC, Cardoso A, Lee S, Vash B, Maiocco S, Mehta R, Strid J, Turajlić S, Reis E Sousa C.   +20 more
europepmc   +1 more source

Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro. [PDF]

J Immunol, 2023
Tondeur EGM, Voerman JSA, Geleijnse MAA, van Hofwegen LS, van Krimpen A, Koerner J, Mishra G, Song Z, Schliehe C.   +8 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function. [PDF]

J Exp Med
Chen D, Wang L, Wen C, Piffko A, Bugno J, Yu X, Wang P, Ji F, Naccasha EZ, Wang J, Huang X, Chmura SJ, Pitroda SP, He C, Liang HL, Weichselbaum RR.   +15 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Antigen cross-presentation potentiating cancer vaccine adjuvant for T cell expansion and synergy with anti-PD-1. [PDF]

NPJ Vaccines
Dang GC, Loeurng V, Pa P, Seng CY, Lee SE, Rhee JH.   +5 more
europepmc   +1 more source

Canvassing Prospects of Glyco-Nanovaccines for Developing Cross-Presentation Mediated Anti-Tumor Immunotherapy. [PDF]

Vaccines (Basel), 2022
Makandar AI, Jain M, Yuba E, Sethi G, Gupta RK.   +4 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine. [PDF]

J Exp Med
Tam H, Shen H, Xu Y, An J, Cyster JG.
europepmc   +1 more source