Results 191 to 200 of about 526,765 (304)

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression. [PDF]

Elife, 2023
Nguyen KB, Roerden M, Copeland CJ, Backlund CM, Klop-Packel NG, Remba T, Kim B, Singh NK, Birnbaum ME, Irvine DJ, Spranger S.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Oncolytic virus M1 reinvigorates CD8⁺ T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen. [PDF]

Cell Mol Immunol
Han Y, Guo C, Chen C, Yang W, Li H, He C, Deng J, Chen Z, Liu W, Chen J, Zhong Y, Yan C, Xu C, Liang X, Zhong S, Chen F, Li D, Li C, Hu W, Chen Z, Mou Y, Chen Z, Yan G, Lim M, Zhu W, Sai K.   +25 more
europepmc   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Viral-Directed Augmentation of Kupffer Cell Cross-Presentation Provokes Antitumor Immunity Against Liver Metastasis. [PDF]

Adv Sci (Weinh)
Chen C, Zhang Q, Li J, Zhou X, Gao D, Li L, Huang D, Wang J, Zeng Z.   +8 more
europepmc   +1 more source

Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer. [PDF]

Nat Commun, 2022
Lu Z, Chen J, Yu P, Atherton MJ, Gui J, Tomar VS, Middleton JD, Sullivan NT, Singhal S, George SS, Woolfork AG, Weljie AM, Hai T, Eruslanov EB, Fuchs SY.   +14 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Commentary Frontiers in ImmunologyThe tricky balancing act of using heat shock proteins for cross-presentation

Frontiers in Immunology, 2012
Willem eVan Eden, Alice eSijts
doaj   +1 more source

Morphology- and adhesion-dual biomimetic nanovaccine boosts antigen cross-presentation through subcellular transport regulation. [PDF]

Sci Adv
Wang Z, Zhou H, Su Q, Qiu Q, Deng W, Zhang M, Xu Z, Li J, Xiao J, Duan X.   +9 more
europepmc   +1 more source