Results 211 to 220 of about 530,471 (260)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders. [PDF]

J Mol Biol
Thomas S, Pak J, Doss-Gollin S, Ryff K, Beijnen E, Pedersen GK, Christensen D, Levy O, van Haren SD.   +8 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Cross-presentation and cancer immunotherapy

, 2012
openaire   +1 more source

Antigen Cross-Presentation by Macrophages [PDF]

Frontiers in Immunology, 2020
The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely. Although originally thought to be an exclusive characteristic of DCs, recently also other immune cells, particularly macrophages, have been shown ...
Elke M Muntjewerff, Luca Meesters, Geert Van Den Bogaart   +2 more
exaly   +6 more sources

Cross-presentation by dendritic cells

Nature Reviews Immunology, 2012
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8(+) T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways.
Sebastian Amigorena, Olivier Joffre, Elodie Segura   +2 more
exaly   +5 more sources

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Cross-presentation by the others

Seminars in Immunology, 2023
The critical role of conventional dendritic cells in physiological cross-priming of immune responses to tumors and pathogens is widely documented and beyond doubt. However, there is ample evidence that a wide range of other cell types can also acquire the capacity to cross-present.
François-Xavier, Mauvais, Peter, van Endert   +1 more
openaire   +2 more sources

Cross-presentation is getting DNGRous

Nature Immunology, 2021
Following internalization of an actin-bearing ligand, the C-type lectin receptor DNGR-1 promotes phagosome rupture, allowing antigens to access the cytosol and be processed through the MHC-I pathway.
Remi Hatinguais, Gordon D. Brown
openaire   +2 more sources

Current Concepts of Antigen Cross-Presentation [PDF]

Frontiers in Immunology, 2018
Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance.
Sven Burgdorf, Maria Embgenbroich, Burgdorf Sven   +2 more
exaly   +4 more sources