Results 231 to 240 of about 530,471 (260)

Phagosomes are competent organelles for antigen cross-presentation

Nature, 2003
The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas ...
Mathieu, Houde, Sylvie, Bertholet, Etienne, Gagnon, Sylvain, Brunet, Guillaume, Goyette, Annie, Laplante, Michael F, Princiotta, Pierre, Thibault, David, Sacks, Michel, Desjardins   +9 more
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The ins-and-outs of endosomal antigens for cross-presentation

Current Opinion in Immunology, 2014
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display several mechanisms to prevent activation of ...
Verena, Schuette, Sven, Burgdorf
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The multiple routes of MHC-I cross-presentation

Trends in Microbiology, 2004
Cross-presentation of phagocytosed antigens on major histocompatibility (MHC) class I molecules is known to occur via two alternative routes; one involving processing and loading of the antigenic peptides inside a vacuolar compartment, the other requiring processing inside the cytosol and loading to MHC-I in the endoplasmic reticulum. A new pathway has
Maria C, Ramirez, Luis J, Sigal
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Cross-presentation by human dendritic cell subsets

Immunology Letters, 2014
Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets differ in their phenotype and functional properties, in particular in their ability to cross-present antigens (i.e. to present exogenous antigens on their MHC class I molecules).
Elodie Segura, Sebastian Amigorena
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Adding to the cross-presentation family

Science, 2018
Immunology Immune responses to viral or tumor antigens are typically initiated by the process of cross-presentation. Cross-presentation is believed to be the major way that innate immune cells, such as the classical dendritic cell 1 (cDC1) subset, activate and prime immunological T cells. Theisen et al.
openaire   +1 more source

The ins and outs of cross-presentation

Nature Immunology, 2003
A recent pair of Nature papers potentially provide some of the missing pieces to the puzzle of how antigens are cross-presented.
openaire   +1 more source

Cross-Presentation in Mouse and Human Dendritic Cells

2015
Cross-presentation designates the presentation of exogenous antigens on major histocompatibility complex class I molecules and is essential for the initiation of cytotoxic immune responses. It is now well established that dendritic cells (DCs) are the best cross-presenting cells.
Elodie, Segura, Sebastian, Amigorena
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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

Cell, 2021
Caetano Reis E Sousa, Naren Srinivasan, Johnathan Canton   +2 more
exaly  

Strategy and clinical application of up-regulating cross presentation by DCs in anti-tumor therapy

Journal of Controlled Release, 2022
Jian You, Yichao Lu
exaly  

Cross Presentation (cross-presentation, cross-priming)

2008
openaire   +1 more source