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The show and tell of cross-presentation
2023Cross-presentation is the culmination of complex subcellular processes that allow the processing of exogenous proteins and the presentation of resultant peptides on major histocompatibility class I (MHC-I) molecules to CD8 T cells. Dendritic cells (DCs) are a cell type that uniquely specializes in cross-presentation, mainly in the context of viral or ...
J Magarian, Blander +3 more
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Cross-presentation of Exogenous Antigens
Transfusion Clinique et Biologique, 2019Presentation of exogenous antigens loaded on major histocompatibility complex class I molecules by antigen presenting cells, termed cross-presentation, is essential for the induction of CD8+ T cells and is performed mainly by specialized dendritic cell subsets.
B, Li, L, Hu
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An invariant road to cross-presentation
Nature Immunology, 2012The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules.
Fei, Duan, Pramod K, Srivastava
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Engineering cross-presentation in vivo
Expert Opinion on Biological Therapy, 2003Apoptotic bodies deliver antigens (Ags) to the cross-presentation pathways of dendritic cells (DCs), where their presentation has been associated with both the maintenance of tolerance as well as the induction of protective immunity. The manner in which apoptotic bodies are generated, their abundance in relation to local DCs, and the milieu in which ...
Michael A, Chattergoon +2 more
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Pathways for antigen cross presentation
Springer Seminars in Immunopathology, 2004Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called "cross presentation" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells.
Guermonprez, P, Amigorena, S
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Cross-Presentation of Antigens by Dendritic Cells
Critical Reviews™ in Immunology, 2002T lymphocytes recognize antigen presented on the surface of antigen-presenting cells byMHC class I and class II molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to ...
Belz, Gabrielle T. +2 more
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Coupling and cross-presentation
Nature, 2005Studies of cultured cells have revealed how the immune system may use intercellular pores to convey information that is important in initiating antiviral responses and in limiting the spread of infections.
William R. Heath, Francis R. Carbone
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Coupled for Cross-Presentation in Tumor Immunotherapy
Science Translational Medicine, 2010Bacterial infection–induced gap junctions in melanoma cells shuttle tumor antigens to immune cells and spur a successful antitumor immune response.
Baoxu, Pang, Jacques, Neefjes
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Defining cross presentation for a wider audience
Current Opinion in Immunology, 2016Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor to a ...
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Dendritic Cells and HCMV Cross-Presentation
2003The outcome of a viral infection is the result of an endless fight between the organism whose task is to mount an antiviral response and the virus that adapts strategies to circumvent the host response. Human cytomegalovirus (HCMV), a latent herpesvirus, can be considered as a spearhead in exploiting co-existence with the host to develop numerous ...
G, Arrode, C, Davrinche
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