Crotoxin Modulates Macrophage Phenotypic Reprogramming [PDF]
Toxins, 2023 Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major
Camila Lima Neves +4 more
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Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4 [PDF]
Mediators of Inflammation, 2016 We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte +7 more
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Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms [PDF]
Toxins, 2022 Crotoxin complex CA/CB and crotamine are the main toxins associated with Crotalus envenomation besides the enzymatic activities of phospholipases (PLA2) and proteases.
Miguel Angel Mejía-Sánchez +5 more
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Antibacterial Properties of Crotoxin from Crotalus durissus terrificus—Insight into the Mechanism of Action [PDF]
Molecules, 2022 The growing problem of antibiotic resistance among bacteria requires searching for new therapeutic agents with bacteriostatic and/or bactericidal properties. Crotoxin is a β-neurotoxin from the venom of the Crotalus durissus terrificus. It is composed of
Dorota Nemecz, Patrycja Golińska
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Formyl Peptide Receptors 1 and 2: Essential for Immunomodulation of Crotoxin in Human Macrophages, Unrelated to Cellular Entry [PDF]
CellsCrotoxin (CTX), the main toxin in Crotalus durissus terrificus venom, is a heterodimeric complex known for its antitumoral, anti-inflammatory, and immunomodulatory properties.
Luciana de Araújo Pimenta +6 more
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Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and ...
Giovana Pedro +6 more
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Elaborating the Role of Natural Products‐Induced Autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art [PDF]
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage.
Ning Wang, Yibin Feng, Beata Pająk
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Crotoxin Modulates Events Involved in Epithelial–Mesenchymal Transition in 3D Spheroid Model [PDF]
Toxins, 2021 Epithelial–mesenchymal transition (EMT) occurs in the early stages of embryonic development and plays a significant role in the migration and the differentiation of cells into various types of tissues of an organism.
Ellen Emi Kato, Sandra Coccuzzo Sampaio
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Snake Venom PLA2 as Anticoagulant Agents: Role of Crotoxin, from Crotalus durissus Rattlesnake, in Hemostasis [PDF]
ToxinsSnake venoms are rich sources of bioactive molecules that modulate hemostasis and, among these, anticoagulant snake venom phospholipases A2 (sPLA2) are found in a range of snake venoms.
Lisele Maria Brasileiro-Martins +11 more
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Crotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity [PDF]
ToxinsNeurotoxicity following South American Crotalus rattlesnake bite is primarily caused by crotoxin, the most abundant component in their venom. Despite the central role of voltage-gated calcium channels (CaV) in neurotransmission, direct targetability by ...
Markus Eicheldinger +5 more
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