Results 161 to 170 of about 1,959 (214)

On the subunit structure of crotoxin: Hydrodynamic and shape properties of crotoxin, phospholipase a and crotapotin

Biochemical and Biophysical Research Communications, 1975
Abstract This paper reports physical-chemical properties of the subunit structure of crotoxin, phospholipase A and crotapotin. The native crotoxin has a sedimentation coefficient of 3S and a radius of gyration of Rg = 16.5 A and a molecular weight of 30,900.
H H, Paradies, H, Breithaupt
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Amino-acid Composition of Crotoxin

Nature, 1951
THE first snake-venom prepared in the pure crystalline form was crotoxin from Crotalus terr. terr. as described in 1938; at that time only its cystine and methionine contents were quantitatively determined1. This protein, with a molecular weight of 30,0002, proved to be homogeneous3 in the ultra-centrifuge2 as well as by electrophoresis4.
K H, SLOTTA, J, PRIMOSIGH
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Crotoxin modulates Encephalitozoon cuniculi-infected macrophages toward the M1 microbicidal profile.

Toxicon
Crotoxin (CTX), a bioactive extract from the snake Crotalus durissus terrificus, has antibacterial, antitumor, and anti-inflammatory properties. Microsporidia are opportunistic, obligate intracellular fungi that infect vertebrates and invertebrates and ...
Cristina Gabriela Nascimento de Oliveira, A. Alvares-Saraiva, E. C. Perez, S. C. Sampaio, M. Lallo   +4 more
semanticscholar   +1 more source

The modulatory effect of Crotoxin and its Phospholipase A2 subunit from Crotalus durrissus terrificus venom on Dendritic Cells interfere with the generation of effector CD4+ T lymphocytes.

Immunology Letters, 2021
Dendritic Cells (DCs) direct either cellular immune response or tolerance. The crotoxin (CTX) and its CB subunit (phospholipase A2) isolated from Crotalus durissus terrificus rattlesnake venom modulate the DCs maturation induced by a TLR4 agonist.
A. P. Freitas, P. B. Clissa, Dunia R. Soto, N. Câmara, E. Faquim-Mauro   +4 more
semanticscholar   +1 more source

Inactivation of crotoxin by group-specific reagents

Biochimica et Biophysica Acta, 1950
Acetylation of most of the amino groups, or esterification of the carboxyl groups of crotoxin causes extensive detoxication. Sulfation of the aliphatic hydroxyl groups, or iodination of most of the phenolic groups, or coupling of these and imidazole groups of the rattlesnake neurotoxin also causes inactivation.
H, FRAENKEL-CONRAT, J, FRAENKEL-CONRAT
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Influence of temperature upon effects of crotoxin and gamma-irradiated crotoxin at rat neuromuscular transmission

Toxicology Letters, 2000
The influence of temperature upon the effects of crotoxin (CTX), from Crotalus durissus terrificus venom, and gamma-irradiated (60Co, 2000 Gy) crotoxin (iCTX) was studied in rat neuromuscular transmission 'in vitro'. Indirect twitches were evoked in the phrenic-diaphragm preparation by supramaximal strength pulses with a duration of 0.5 ms and ...
Gallacci, M., Nascimento, N., Rogero, JR, Vassilieff, V. S.   +3 more
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Comparative analysis of paralytic and myotoxic effects of Crotalus durissus terrificus venom and crotoxin from different regions of Minas Gerais, Brazil.

Toxicon
PURPOSE Crotalus durissus terrificus, commonly known as the South American rattlesnake, is a snake of medical relevance in Brazil. Its wide geographical distribution correlates with biochemical variations in venom composition, which can affect the ...
Natália Muradas Valério Souza, Êmylle Karoline Ramos Pinto, Fernanda Valadares Maciel, Thales Augusto Gonçalves de Abreu, P. L. Ortolani, C. L. Fortes-Dias, Walter Luís Garrido Cavalcante   +6 more
semanticscholar   +1 more source

Re-examination of crotoxin-membrane interactions

Toxicon, 1996
The interaction of crotoxin with synaptic membranes from Torpedo marmorata has been re-examined, using radioiodinated toxin. In competition experiments, the 'saturable binding' is usually calculated by subtracting the non-saturable binding, determined in the presence of an excess of unlabelled crotoxin, from total binding.
I, Krizaj, G, Faure, F, Gubensek, C, Bon
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Antitumor and antiproliferative potential of crotoxin in triple negative breast tumors.

Toxicon
Triple negative breast carcinoma represents around 15 % of breast cancer cases. Is a type of breast cancer with poor prognosis, because it has a high rate of recurrence, metastasis and death and can be resistant to therapy.
De Andrade Camila Marques, Machado Cleni Mara Marzocchi, De Castro Fabíola Attié, Teixeira Natércia, Amaral Cristina, C. Felipe, Canicoba Nathália Cristina, Torqueti Maria Regina   +7 more
semanticscholar   +1 more source

Preparation of a crotoxin neutralizing monoclonal antibody

Toxicon, 1988
Crotoxin is a heterodimeric protein composed of an acidic and basic subunit from the venom of Crotalus durissus terrificus and is representative of a number of presynaptically acting neurotoxins found in the venom of rattlesnakes. Four different monoclonal antibodies, typed as IgG1 subclass, were raised against the basic subunit of this toxin.
I I, Kaiser, J L, Middlebrook
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