Results 171 to 180 of about 1,959 (214)

Crotoxin

2000
Abstract Crotoxin is a dimeric polypeptide (molecular mass, 23.5 kDa) from the venom of the southern Brazilian rattlesnake (Crotalus durissus terrifi,cus) (8,11). The agent acts pre synaptically at motor nerve terminals. In isolated nerve muscle preparations, its effect on transmitter release occurs in three stages (2): An initial ...
openaire   +1 more source

Cytotoxicity of crotoxin on murine erythroleukemia cellsin vitro

Investigational New Drugs, 1993
The cytotoxic effect of crotoxin, a heterodimeric phospholipase A2 from the venom of Crotalus durissus terrificus, was examined on murine erythroleukemia cells in vitro. Crotoxin cytocidal effect on cell growth had an EC50 of approximately 0.1-0.2 microM (3.0-5.0 micrograms/ml) in serum-free medium.
J C Vidal
exaly   +3 more sources

Activation of crotoxin B by volvatoxin A2

Biochemical and Biophysical Research Communications, 1976
Abstract Of the two proteins making up volvatoxin, a mushroom toxin, the smaller, volvatoxin A2, of molecular weight 25,000, is able to synergistically increase the low neurotoxicity of crotoxin B, the larger basic component of the Crotalus durissus terrificus neurotoxin, crotoxin.
T W, Jeng, H, Fraenkel-Conrat
openaire   +2 more sources

Myotoxicity of Crotoxin on C2C12 Myoblasts and its Inhibition by Crotalus Neutralizing Factor versus Enhanced Resistance in Myotubes: Exploring Toxicity and Membrane Potential.

Current protein and peptide science
BACKGROUND Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2) inhibitor present in the blood of Crotalus durissus terrificus snake. Particularly, CNF inhibits the toxic action of Crotoxin (CTX), which is a major neurotoxin found in C.
M. N. M. Tavares, Micaela de Melo Cordeiro Eulálio, H. M. Santana, C. N. Boeno, V. P. Dos Reis, Cristina Matiele Alves Rego, A. F. Ferreira, M. V. Paloschi, A. M. Soares, C. L. Fortes-Dias, S. S. Setúbal, J. Zuliani   +11 more
semanticscholar   +1 more source

Induction of tolerance to crotoxin in mice.

The Journal of Pharmacology and Experimental Therapeutics, 1993
Crotoxin, the major toxic component from the venom of Crotalus durissus terrificus is a potent neurotoxin (LD50, i.p., mice, 0.09 mg/kg) which possesses phospholipase A2 activity and causes a blockade of neuromuscular transmission. In this article, we show that mice injected daily with progressively increasing doses of crotoxin develop tolerance to the
M, Okamoto, L J, Viskatis, G, de la Roza, J C, Vidal   +3 more
openaire   +2 more sources

Venomics and biochemical analysis of the black-tailed horned pitviper, Mixcoatlus melanurus, and characterization of Melanurutoxin, a novel crotoxin homolog.

Journal of Proteomics, 2020
We report a structural and functional venomics characterization of the black-tailed horned pitviper, Mixcoatlus melanurus. The venom phenotype of this small and elusive pitviper endemic to México comprise peptides and proteins of 16 toxin families whose ...
E. Neri-Castro, L. Sanz, A. Olvera-Rodríguez, Melisa Bénard-Valle, A. Alagón, J. Calvete   +5 more
semanticscholar   +1 more source

Systemic skeletal muscle necrosis induced by crotoxin

Toxicon, 2001
Systemic skeletal muscle necrosis induced by crotoxin, the major component of the venom of Crotalus durissus terrificus, was investigated. Mice received an intramuscular injection of crotoxin (0.35mg/kg body weight) into the right tibialis anterior (TA) muscles, which were evaluated 3h, 24h and 3 days later.
T F, Salvini, A C, Amaral, E H, Miyabara, J A, Turri, P M, Danella, H S, Selistre de Araújo   +5 more
openaire   +2 more sources

Effects of crotoxin on the isolated guinea pig heart

Toxicon, 1990
The effects of crotoxin, isolated from the venom of the South American rattlesnake, Crotalus durissus terrificus, were investigated on isolated guinea pig hearts, perfused with Locke solution, by the Langendorff method. The cardiac beats and the electrocardiogram were simultaneously registered and the creatine kinase (CK) activity of the perfusate ...
P E, Santos, S D, Souza, L, Freire-Maia, A P, Almeida   +3 more
openaire   +2 more sources

Engineered protein containing crotoxin epitopes induces neutralizing antibodies in immunized rabbits.

Molecular Immunology, 2020
Crotoxin (Ctx) is the main lethal component of Crotalus durissus terrificus venom. It is a neurotoxin, composed of two subunits associated by noncovalent interactions, the non-toxic acid subunit (CA), named Crotapotin, and the basic subunit (CB), with ...
Denis A. Molina Molina, C. Guerra-Duarte, F. Costal-Oliveira, Elizângela Almeida Rocha, Carolina Rego Rodrigues, R. Machado-de-Ávila, V. Soccol, C. Chávez-Olórtegui   +7 more
semanticscholar   +1 more source

Investigations on the mechanism of action of crotoxin.

Journal de physiologie, 1985
Crotoxin, the major toxic protein of Crotalus durissus terrificus, is composed of a basic phospholipase, component-B, and of an acidic subunit, component-A. The crotoxin complex is insensitive to an active site directed reagent, p-bromophenacyl bromide, while its isolated enzymatic component-B is rapidly and irreversibly inactivated.
F, Radvanyi, C, Bon
openaire   +2 more sources