Results 11 to 20 of about 1,795 (192)

HETEROLOGOUS EXPRESSION AND PURIFICATION OF RECOMBINANT CROTOXIN B, THE PHOSPHOLIPASE A2 SUBUNIT OF CROTOXIN

Studia Universitatis Babes-Bolyai Chemia, 2018
Crotoxin is a heterodimeric β-neurotoxin isolated from the venom of Crotalus durissus terrificus, consisting of two, non-covalently bound subunits, crotapotin (CA) and crotoxin B (CB).
Francisc-Andrei BODA, Pál SALAMON, Csongor ORBÁN, Lavinia-Anda BERȚA, Augustin CURTICĂPEAN, Șerban-Andrei GÂZ, Maria DOGARU   +6 more
doaj   +2 more sources

The Proteome of African Spitting and Non-Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells. [PDF]

J Appl Toxicol
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Offor BC, Muller B, Motadi LR, Piater LA.   +3 more
europepmc   +2 more sources

Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms [PDF]

Frontiers in Pharmacology
Introduction: Melanoma, a highly aggressive skin cancer originating in melanocytes, poses a significant threat due to its metastatic potential. While progress has been made in treating melanoma with targeted therapies and immunotherapies, challenges ...
Tamires Cunha Almeida, Karina Cristina Giannotti, Lorena Morais Ribeiro Silva, Rafael Marques-Porto, Carlos DeOcesano-Pereira, Lauren Camargo, Ana Marisa Chudzinski-Tavassi, Paul Reid, Gisele Picolo   +8 more
doaj   +2 more sources

Immunorecognition and Neutralization of Crotalus durissus cumanensis Venom by a Commercial Antivenom Produced in Colombia [PDF]

Toxins, 2022
In Colombia, on average 2.9% of the nearly 5600 snakebite events that occur annually involve the rattlesnake Crotalus durissus cumanensis. The envenomation by this snake is mainly characterized by neurotoxicity and the main toxin is crotoxin (~64.7% of ...
Augusto Acosta-Peña, Vitelbina Núñez, Jaime Andres Pereañez, Paola Rey-Suárez   +3 more
doaj   +2 more sources

Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle. [PDF]

PLoS ONE, 2017
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described.
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim   +12 more
doaj   +6 more sources

Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]

PLoS Neglected Tropical Diseases
BackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini, Anderson M Rocha, Luciana A Freitas-de-Sousa, Alison F A Chaves, Solange M T Serrano, Vinicius C Souza, Vincent L Viala, Inácio L M Junqueira-Azevedo, Felipe A Cerni, Marco A Sartim, Jacqueline A G Sachett, Wuelton M Monteiro, Felipe G Grazziotin, Fan Hui Wen, Manuela B Pucca, Ana M Moura-da-Silva   +15 more
doaj   +2 more sources

Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia [PDF]

Toxins, 2022
Biochemical and biological differences in the venom of Crotalus durissus cumanensis from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three
Ariadna Rodríguez-Vargas, Nohora Vega, Edgar Reyes-Montaño, Gerardo Corzo, Edgar Neri-Castro, Herlinda Clement, Francisco Ruiz-Gómez   +6 more
doaj   +2 more sources

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions [PDF]

Mediators of Inflammation, 2001
Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2.
Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky   +4 more
doaj   +2 more sources

Crotoxin-Loaded Silica Nanoparticles: A Nanovenom Approach [PDF]

Pharmaceutics
Background: Ophidism is a globally neglected health problem. In Argentina, Crotalus durissus terrificus (C.d.t., South American rattlesnake) is one of the species of greatest medical importance since its venom contains mainly crotoxin (CTX), a potent ...
Florencia Silvina Conti, Exequiel Giorgi, Laura Montaldo, Juan Pablo Rodríguez, Mauricio Cesar De Marzi, Federico Gastón Baudou   +5 more
doaj   +2 more sources

3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line [PDF]

Molecules
Breast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast cancer (TNBC) presents the worst prognosis due to its aggressive nature and the absence of
Patricia Bezerra, Eduardo F. Motti
doaj   +2 more sources