Results 51 to 60 of about 1,795 (192)

The Projective Field of a Retinal Amacrine Cell [PDF]

, 2011
In sensory systems, neurons are generally characterized by their receptive field, namely the sensitivity to activity patterns at the input of the circuit. To assess the role of the neuron in the system, one must also know its projective field, namely the
Baccus, Stephen A., de Vries, Saskia E. J., Meister, Markus   +2 more
core   +1 more source

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2017
Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes.
Catherine A Vulfius, Igor E Kasheverov, Elena V Kryukova, Ekaterina N Spirova, Irina V Shelukhina, Vladislav G Starkov, Tatyana V Andreeva, Grazyna Faure, Marios Zouridakis, Victor I Tsetlin, Yuri N Utkin   +10 more
doaj   +1 more source

Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang, Ji-Fu Wei   +5 more
wiley   +1 more source

Medicinal and ethnoveterinary remedies of hunters in Trinidad [PDF]

, 2001
Background Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. Results Plants used include Piper hispidum,
M Heinrich, NL Etkin, S Moodie-Kublalsingh, R Wall, ME Alkins, SA Nishioka, JC Murphy, MT Jorge, J Kenny, LD George Angus, MJ Hutt, P Melo, JO Boos, CH Browner, G Bourdy, WH Hodge, DS Nunes, J Serpell, EB Russo, EF Im Thurn, E Roth Walter, RR Mole, PA Dennis, D Hazlett, JA Duke, MJ Martínez-Lirola, AB Carr, E Davis, W Wilbert, Bonnie Beaver, G Urton, WV Branan, AL Fuly, I Francischetti, R Otero, HC Castro, L Thomas, NA Pereira, H Wagner, PJ Houghton, R Ejzemberg, MS Abubakar, W Martz, R Reyes-Chilpa, O Castro, PA Melo, A Borges, H Daisley, CM McCorkle, JA Duke, JF Morton, W Wong, FG Coe, DA Lachman-White, LM Girón, JJ Moreno, C Yoosook, P Tuntiwachwuttikul, RH Cichewicz, H Wagner, B Frei, AA Al-Qarawi, SC Comerford, W Wilbert, PN Honychurch, R Verpoorte, R Otero, I Indrayanto, K Inoue, E Osim, J Laferriere, W Setzer, MW Bernart, WB Mors, Anon, AJJ Van den Berg, LF Villegas, C Hufford, IT Matsuse, RP Labadie, JF Morton, JF Morton, S Horsten, JF Morton, RE Omoregbe, B Das, C Auvin-Guette, WD MacRae, JX de-Vries, MP Gupta, J Mills, C Desmarchelier, JA Duke, C Desmarchelier, C Desmarchelier, C Desmarchelier, E Mongelli, WR Stimson, ML Tan, R Hegnauer, T Plowman, MA Kay, R Hansel, R Hegnauer, L Joly, V Muñoz, T Arnason, FG Coe, JB Calixto, NV Rajeshkumar, KCS Chen Liu, KS Satyan, ARS Santos, B Burke, MO Nwosu, K Jenett-Siems, H Hirschhorn, F Ayala Flores, B-N Zhou, J-L Longuefosse, R Novaretti, D Rivera, E Yesilada, E Blanco, A Cáceres, R Hegnauer, R Hegnauer, A Filipov, A Cáceres, G Schmeda-Hirschmann, VS Frutuoso, AK Bhargava, FI Freire M de, J Jakupovic, S Borkosky, R Hegnauer, R Otero, C Lans   +137 more
core   +2 more sources

Bactericidal effects of snake venom phospholipases A2: a systematic review and analysis of minimum inhibitory concentration [PDF]

, 2023
Background: Infections caused by multi-drug resistance (MDR) strains are potentially fatal public health issues worldwide that need pressing attention.
Abdullahi, Zainab U., Abu-Odah, Hammoda, Ahmad, Ayman, Bello, Umar, Lawan, Abdulmalik, Musa, Salihu S.   +5 more
core   +1 more source

Crotalus durissus terrificus venom as a source of antitumoral agents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase ...
MA Soares, PB Pujatti, CL Fortes-Dias, L Antonelli, RG Santos   +4 more
doaj   +1 more source

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]

, 2011
Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena, Dennis, Siobhan, Hanley, Jonathan G., Henley, Jeremy M., Jaafari, Nadia, Mellor, Jack R.   +5 more
core   +1 more source

Ethnopharmacological Survey of Medicinal Plants Used by Traditional Healers and Indigenous People in Chittagong Hill Tracts, Bangladesh, for the Treatment of Snakebite

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Snakebites are common in tropical countries like Bangladesh where most snakebite victims dwell in rural areas. Among the management options after snakebite in Bangladesh, snake charmers (Ozha in Bengali language) are the first contact following a snakebite for more than 80% of the victims and they are treated mostly with the help of some medicinal ...
Mohammad Fahim Kadir, James Regun Karmoker, Md. Rashedul Alam, Syeda Rawnak Jahan, Sami Mahbub, M. M. K. Mia, Rainer W. Bussmann   +6 more
wiley   +1 more source

The Presence and Distribution of Crotoxin in the Rock Rattlesnake (Crotalus lepidus) [PDF]

, 2022
Crotoxin and its homologs (hereafter all referred to as CTx) is a highly lethal heterodimeric beta-neurotoxin found in pitvipers (Crotalinae) and is the main driver of neurotoxic venom phenotypes (Type II). In contrast, hemorrhagic venom phenotypes (Type
Mellor, Jade
core   +1 more source

Camelid Single-Domain Antibodies (VHHs) against Crotoxin: A Basis for Developing Modular Building Blocks for the Enhancement of Treatment or Diagnosis of Crotalic Envenoming

Toxins, 2018
Toxic effects triggered by crotalic envenoming are mainly related to crotoxin (CTX), composed of a phospholipase A2 (CB) and a subunit with no toxic activity (CA).
Marcos B. Luiz, Soraya S. Pereira, Nidiane D. R. Prado, Naan R. Gonçalves, Anderson M. Kayano, Leandro S. Moreira-Dill, Juliana C. Sobrinho, Fernando B. Zanchi, André L. Fuly, Cleberson F. Fernandes, Juliana P. Zuliani, Andreimar M. Soares, Rodrigo G. Stabeli, Carla F. C. Fernandes   +13 more
doaj   +1 more source