Results 61 to 70 of about 1,795 (192)

Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira, Rui Seabra Ferreira, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos, Daniel Carvalho Pimenta   +6 more
doaj   +1 more source

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a ...
Leonardo A. Calderon, Juliana C. Sobrinho, Kayena D. Zaqueo, Andrea A. de Moura, Amy N. Grabner, Maurício V. Mazzi, Silvana Marcussi, Auro Nomizo, Carla F. C. Fernandes, Juliana P. Zuliani, Bruna M. A. Carvalho, Saulo L. da Silva, Rodrigo G. Stábeli, Andreimar M. Soares, Fernando Albericio   +14 more
wiley   +1 more source

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin [PDF]

, 2017
Local myonecrosis resulting from snakebite envenomation is not efficiently neutralized by regular antivenom administration. This limitation is considered to be a significant health problem by the World Health Organization.
Cavalcante, W. L. G., Dreyer, Thiago R., Fontes, M.R.M., Gallacci, M., Matioli, F. F., Salvador, G. H. M., Santos, J. I. dos, Velázquez-Campoy, Adrián   +7 more
core   +1 more source

Biological Roles of the Two Components of Crotoxin [PDF]

Proceedings of the National Academy of Sciences, 1971
Crotoxin, the Brazilian rattlesnake neurotoxin, generally behaves as a homogeneous protein; however, it is a molecular complex of an acidic and a basic protein. These can be separated after alkylation or acylation of the amino groups, or on carboxymethyl cellulose at pH 4, or on DEAE-cellulose in 6 M urea. The two proteins differ greatly in composition,
R A, Hendon, H, Fraenkel-Conrat
openaire   +2 more sources

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago, Edgar Alejandro Pinos Tamayo, Daniel Moreira dos Santos, Bonglee Kim, José R. Almeida, Rosy Iara Maciel de Azambuja Ribeiro, Marco Eigenfeld   +6 more
wiley   +1 more source

An Evaluation of 3‐Rhamnosylquercetin, a Glycosylated Form of Quercetin, against the Myotoxic and Edematogenic Effects of sPLA2 from Crotalus durissus terrificus

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
This paper shows the results of quercitrin effects on the structure and biological activity of secretory phospholipase (sPLA2) from Crotalus durissus terrificus, which is the main toxin involved in the pharmacological effects of this snake venom. According to our mass spectrometry and circular dichroism results, quercetin was able to promote a chemical
Daniela de Oliveira Toyama, Henrique Hessel Gaeta, Marcus Vinícius Terashima de Pinho, Marcelo José Pena Ferreira, Paulete Romoff, Fábio Filippi Matioli, Angelo José Magro, Marcos Roberto de Mattos Fontes, Marcos Hikari Toyama, Kota V. Ramana   +9 more
wiley   +1 more source

Snake venomics and antivenomics of Middle and South America rattlesnakes.Identification of neurotoxin crotoxin as an adaptive trait during Crotalus Durissus invasion of South America [PDF]

, 2009
Comunicaciones a ...
Alape-Girón, Alberto, Calvete, Juan J., Escolano, José, Flores-Díaz, Marietta, Gutiérrez, J.M., Sanz, Libia, Sasa, Mahmood   +6 more
core  

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
In this study, we evaluated the actions of Crotalus durissus cumanensis venom (CDCmV), and its crotoxin (Crtx) fraction, on renal and vascular functions in Wistar rats.
TP Pereira, RRPP Bezerra de Menezes, AFC Torres, TS Brito, FJ Batista-Lima, JFC Vinhote, DF Sousa, RM Ximenes, MH Toyama, EBS Diz Filho, PJC Magalhães, HSA Monteiro, AMC Martins   +12 more
doaj   +1 more source

Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype [PDF]

Scientific Reports, 2019
AbstractCrotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels. Angiogenesis has a key role in tumour growth and progression and is regulated by macrophage secretory activity.
de Araújo Pimenta, Luciana, de Almeida, Maíra Estanislau S., Bretones, Marisa Langeani, Cirillo, Maria Cristina, Curi, Rui, Sampaio, Sandra Coccuzzo   +5 more
openaire   +2 more sources

Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)

International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014
Eclipta alba can be found growing wild in fallow lands of Bangladesh where it is considered as a weed by farmers. Traditional medicinal systems of the Indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract ...
Rownak Jahan, Abdullah Al-Nahain, Snehali Majumder, Mohammed Rahmatullah, Jagadananda Ghosh   +4 more
wiley   +1 more source