Results 31 to 40 of about 851,067 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Using meta‐analysis to understand the impacts of dietary protein and fat content on the composition of fecal microbiota of domestic dogs (Canis lupus familiaris): A pilot study

open access: yesMicrobiologyOpen
The interplay between diet and fecal microbiota composition is garnering increased interest across various host species, including domestic dogs.
Francis D. Phimister   +8 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

The effect of fertilisation on the nutritional value of alfalfa-grass mixtures in the Right-Bank Forest-Steppe

open access: yesРослинництво та ґрунтознавство, 2021
One of the ways to reduce protein deficiency and produce complete feed is the cultivation of alfalfa-grass mixtures, which, due to the optimal ratio of protein and carbohydrate compounds, mineral salts and other valuable biologically active substances ...
I. Svystunova   +4 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Influence of Addition Crude Fish Oil (CFO) in White Shrimp (Litopenaeus vannamei) Feed to Cholesterol Content and Fat Retention in Meat [PDF]

open access: yes, 2015
White shrimp are aquatic organisms consumed by many people and a source of animal protein and fat needed by humans. Shrimp also require fat as a source of energy and metabolic processes to maximize growth.
Agustono   +2 more
core   +1 more source

Preliminary study on the effect of milling technology on the key components of rice bran

open access: yesLiang you shipin ke-ji, 2020
To improve the utilization level of rice bran, it is very important to study the accurate separation of key components in rice bran. In this paper, the influence of grinding wheel type, grinding speed and grinding time on the contents of key components ...
YANG Kai-zhou   +6 more
doaj   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, Accepted Article.
Objective To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE). Methods We analyzed cross‐sectional data from 451 adults in the Approaches to Positive, Patient‐centered Experiences of ...
Sarah L. Patterson   +7 more
wiley   +1 more source

Laser‐Induced Graphene from Waste Almond Shells

open access: yesAdvanced Functional Materials, EarlyView.
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova   +9 more
wiley   +1 more source

The effect of supplementation perilla seeds (Perilla frutescens) in the diets on feed consumption and digestibility nutrients on ducks

open access: yesJurnal Ilmu-Ilmu Peternakan, 2022
This study aims to determine the digestibility of perilla seeds (Perilla frutescens) in 3 levels (0, 2.5, and 5%) in rations given to local ducks. The research material used was male Mojosari ducks (Day Old Duck) with as many as 90 tails, with an average
Rendi Fathoni Hadi   +2 more
doaj   +1 more source

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