Results 91 to 100 of about 534 (117)

PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation

Journal of Virology
ABSTRACT Viruses exploit the host cell’s energy metabolism system to support their replication. Mitochondria, known as the powerhouse of the cell, play a critical role in regulating cell survival and virus replication.
Xiaodi Liu, Quanhui Yan, Xueyi Liu, Wenkang Wei, Linke Zou, Feifan Zhao, Sen Zeng, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen, Shuangqi Fan   +11 more
openaire   +2 more sources

Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH

mBio
Classical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li, Yaoyao Huang, Xueyi Liu, Lihong Zhang, Xinyan Wang, Feifan Zhao, Linke Zou, Keke Wu, Wenxian Chen, Yuwei Qin, Sen Zeng, Bingke Li, Yintao He, Yiwan Song, Zhaoyao Li, Jindai Fan, Mingqiu Zhao, Lin Yi, Hongxing Ding, Shuangqi Fan, Jinding Chen   +20 more
doaj   +1 more source

COP I vesicles facilitate classical swine fever virus proliferation by transporting fatty acid synthase from the Golgi apparatus to the endoplasmic reticulum

Journal of Virology
Classical swine fever virus (CSFV) is an enveloped, positive-sense, single-stranded RNA virus in the Flaviviridae family that remodels the cell’s endomembrane for its own propagation.
Liang Zhang, Tao Wang, Chen Chen, Mengzhao Song, Ning Li, Bihao Luo, Yuehan Quan, Kangkang Guo, Yanming Zhang   +8 more
doaj   +1 more source

PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation

Virulence
Viruses hijack host metabolic resources for replication. Previous studies have shown that classical swine fever virus (CSFV) infection induces host lipid metabolic reprogramming.However, research into the exact regulatory mechanisms between CSFV and ...
Bingke Li, Linke Zou, Chenchen Sun, Jianan Jiang, Shurou Li, Jiaxin Wang, Yintao He, Yuwei Qin, Sen Zeng, Yiwan Song, Weijun Zeng, Lin Yi, Shuangqi Fan, Jinding Chen, Keke Wu   +14 more
doaj   +1 more source

Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budding

mBio
Classical swine fever virus (CSFV) incurs substantial economic losses in the global swine industry due to its persistent emergence and re-emergence across various countries.
Jinxia Chen, Hanfei Yang, Mingyue Wan, Yan Cheng, Jishan Bai, Yuhang Li, Jing Chen, Bingqian Zhao, Fei Gao, Bin Zhou   +9 more
doaj   +1 more source

Rescue of the CSFV Koslov strain from a cloned cDNA

, 2014
Fahnøe, Ulrik, Belsham, Graham, Höper, Dirk, Beer, Martin, Rasmussen, Thomas Bruun   +4 more
openaire   +1 more source

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Genotypic diversity of CSFV field strains: A silent risk reduces vaccination efficacy of CSFV vaccines in Vietnam

Virology, 2022
Classical swine fever (CSF) is a highly contagious, devastating, and transboundary viral disease that afflicts swine industries worldwide. Immunization with vaccines is one of the most effective strategies for controlling this disease. However, shifts in the antigenicity and pathogenicity of novel evolving viral strains have the potential to evade ...
Ngoc Hai Nguyen, Phuong Binh Thi Nguyen, Trung Quan Nguyen, Duy Tien Do, My Duyen Thi Nguyen, Minh Nam Nguyen   +5 more
openaire   +2 more sources

Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV

Antiviral Research, 2023
Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious diseases of pigs. Most pig farms in China are immunized against these two diseases. Here, we describe a stabilized E2 protein as an immunogen inserted into the PRV genome as a bivalent live virus-vectored vaccine.
Yang-yang Sun, Ke-shu Liu, Cun Zhang, Zheng Ni, Yin-chu Zhu, Hai-li Bao, Liu Chen, Wei-cheng Ye, Jiong-gang Hua, Su-xin Huo, Hong-yu Wang, Tao Yun, En-dong Bao   +12 more
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Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV

Antiviral Research, 2020
Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and novel sub-subgenotypes of CSFV ...
Wu, Tong, Hao, Zheng, Guo-Xin, Li, Fei, Gao, Tong-Ling, Shan, Yan-Jun, Zhou, Hai, Yu, Yi-Feng, Jiang, Ling-Xue, Yu, Li-Wei, Li, Ning, Kong, Guang-Zhi, Tong, Ji-Chang, Li   +12 more
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Broad neutralization of CSFV with novel monoclonal antibodies in vivo

International Journal of Biological Macromolecules, 2021
Classical swine fever is a highly contagious disease in China. Although vaccination against Classical swine fever virus (CSFV) has been widely carried out in China, CSFV cases still emerge in an endless stream. Therefore, it is necessary to take new antiviral measures to eliminate CSFV.
Huiling, Xu, Guangwei, Han, Ying, Lu, Zehui, Liu, Lina, Tao, Fang, He   +5 more
openaire   +2 more sources