Results 41 to 50 of about 9,582 (257)

PCBP1 Deficient Pigs Hold the Potential to Inhibit CSFV Infection [PDF]

, 2021
AbstractClassical swine fever virus (CSFV), pathogen of classic swine fever, has caused severe economic losses worldwide. Poly (rC)-binding protein 1 (PCBP1), interacting with Npro of CSFV, plays a vital role in CSFV growth. Here, our research is the first report to generate PCBP1 knockout pigs via gene editing technology.
Chunyun Qi, Daxin Pang, Kang Yang, Shuyu Jiao, Heyong Wu, Chuheng Zhao, Lanxin Hu, Feng Li, Jian Zhou, Lin Yang, Dongmei Lv, Xiaochun Tang, Hongsheng Ouyang, Zicong Xie   +13 more
openalex   +2 more sources

Development and Application of RAA Nucleic Acid Test Strip Assay and Double RAA Gel Electrophoresis Detection Methods for ASFV and CSFV

Frontiers in Molecular Biosciences, 2022
African swine fever (ASF) is an acute, severe and hemorrhagic infectious disease caused by African swine fever virus (ASFV) infecting domestic pigs and wild boars. Since the outbreak of the disease in China in 2018, it has brought a great impact on China’
Keke Wu, Yuanyuan Zhang, S. Zeng, Xiaodi Liu, Yuwan Li, Xiaowen Li, Wenxian Chen, Zhaoyao Li, Yuwei Qin, Jinding Chen, Shuangqi Fan   +10 more
semanticscholar   +1 more source

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protect Pigs against a Virulent CSFV Challenge

Viruses, 2023
Classical swine fever (CSF) remains one of the most economically significant viral diseases affecting domestic pigs and wild boars worldwide. To develop a safe and effective vaccine against CSF, we have constructed a triple gene-deleted pseudorabies virus (PRVtmv)-vectored bivalent subunit vaccine against porcine circovirus type 2b (PCV2b) and CSFV ...
Ediane Silva, Elizabeth Medina-Ramirez, Selvaraj Pavulraj, Douglas P. Gladue, Manuel Borca, Shafiqul I. Chowdhury   +5 more
openaire   +3 more sources

Antiviral activity of ISG15 against classical swine fever virus replication in porcine alveolar macrophages via inhibition of autophagy by ISGylating BECN1

Veterinary Research, 2020
Interferons (IFNs) induce the expression of interferon-stimulated genes (ISGs) for defense against numerous viral infections, including classical swine fever virus (CSFV). However, the mechanisms underlying the effect of ISGs on CSFV infection are rarely
Cheng Li, Yifan Wang, Hongqing Zheng, Wang Dong, Huifang Lv, Jihui Lin, Kangkang Guo, Yanming Zhang   +7 more
doaj   +1 more source

MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells

Emerging Microbes and Infections, 2020
Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the Flaviviridae family. To date, the host factors required for CSFV entry remain poorly characterized.
Guanglai Zheng, Lian-Feng Li, Yuexiu Zhang, Liang Qu, Wenjing Wang, Miao Li, Shaoxiong Yu, Mo Zhou, Yuzi Luo, Yuan Sun, Muhammad Munir, Su Li, Hua-Ji Qiu   +12 more
doaj   +1 more source

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis

iScience, 2022
Summary: An emerging topic in virology is that viral replication is closely linked with the metabolic reprogramming of host cells. Understanding the effects of reprogramming host cell metabolism due to classical swine fever virus (CSFV) infection and the
Xiaodong Zou, Yang Yang, Feng Lin, Jiahuan Chen, Huanyu Zhang, Linquan Li, Hongsheng Ouyang, Daxin Pang, Linzhu Ren, Xiaochun Tang   +9 more
doaj   +1 more source

Adverse Effects of Classical Swine Fever Virus LOM Vaccine and Jeju LOM Strains in Pregnant Sows and Specific Pathogen-Free Pigs

Pathogens, 2019
In Jeju island of South Korea, a classical swine fever (CSF) non-vaccinated region, many pig farmers insisted on abortion and stillbirth in pregnant sows and high mortality of suckling/weaning piglets by circulating CSF virus from 2014 to 2018.
SeEun Choe, Jae-Hoon Kim, Ki-Sun Kim, Sok Song, Ra Mi Cha, Wan-Choul Kang, Hyeun-Ju Kim, Gyu-Nam Park, Jihye Shin, Hyoung-Nam Jo, In-Soo Cho, Bang-Hun Hyun, Bong-Kyun Park, Dong-Jun An   +13 more
doaj   +1 more source

Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus

Viruses, 2023
Classical swine fever virus (CSFV), which is a positive-sense, single-stranded RNA virus with an envelope, is a member of the Pestivirus genus in the Flaviviridae family.
Xin Guo, Maolin Zhang, Xiaomin Liu, Yannan Zhang, Chongyang Wang, Yidi Guo   +5 more
doaj   +1 more source

Spatio-temporal epidemic modelling using additive-multiplicative intensity models [PDF]

, 2008
An extension of the stochastic susceptible-infectious-recovered (SIR) model is proposed in order to accommodate a regression context for modelling infectious disease surveillance data. The proposal is based on a multivariate counting process specified by
Höhle, Michael
core   +1 more source

Factors associated with the introduction of classical swine fever virus into pig herds in the central area of the 1997/98 epidemic in the Netherlands [PDF]

, 2001
A matched case-control study of 135 infected and 99 uninfected pig herds from the central area of the 1997 to 1998 epidemic of classical swine fever (CSF) in The Netherlands was undertaken to identify factors associated with the introduction of the virus.
Elbers, A.R.W., Jong, M.C.M., de, Stegeman, J.A.   +2 more
core   +2 more sources