Results 81 to 90 of about 534 (117)

Computational investigation in inhibitory effects of amantadine on classical swine fever virus p7 ion channel activity

Scientific Reports
Classical swine fever virus (CSFV) p7 viroporin plays crucial roles in cellular ion balance and permeabilization. The antiviral drug amantadine effectively inhibits viral replication by blocking the activity of CSFV p7 viroporin.
Xiaowei Chen, Xiao Wang
doaj   +1 more source

Rapid Differential Detection of Wild-Type Classical Swine Fever Virus and Hog Cholera Lapinized Virus Vaccines by TaqMan MGB-Based Dual One-Step Real-Time RT-PCR

Veterinary Sciences
To establish a rapid real-time RT-PCR method for differentiating wild-type classical swine fever virus (CSFV) strains from vaccine strains (HCLV), we designed a universal primer targeting the NS3 gene to detect wild-type CSFV strains and vaccine strains ...
Yongzhe Zhang, Meiqi Wang, Yajuan Sun, Xingyu Xiao, Songsong Wang, Peng Li, Yansong Liu, Hongri Zhao, Yan Meng, Rui Yin   +9 more
doaj   +1 more source

Antiviral Role of IFITM Proteins in Classical Swine Fever Virus Infection

Viruses, 2019
The proteins IFITM1, IFITM2, and IFITM3 are host effectors against a broad range of RNA viruses whose roles in classical swine fever virus (CSFV) infection had not yet been reported.
Cheng Li, Hongqing Zheng, Yifan Wang, Wang Dong, Yaru Liu, Liang Zhang, Yanming Zhang   +6 more
doaj   +1 more source

Rab27a-mediated exosome secretion facilitates classical swine fever virus release and immune evasion

Journal of Virology
Classical swine fever is a highly contagious disease caused by the classical swine fever virus (CSFV), a member of the Flaviviridae family. Exosomes are extracellular vesicles that mediate intercellular communication by transferring membrane components ...
Ning Li, Yuehan Quan, Bihao Luo, Xinxin Chen, Tao Wang, Zifeng Gong, Liang Zhang, Kangkang Guo   +7 more
doaj   +1 more source

Identification of E2 with improved secretion and immunogenicity against CSFV in piglets

BMC Microbiology, 2020
Background Outbreaks of Classical swine fever virus (CSFV) cause significant economic losses in the swine industry. Vaccination is the major method to prevent and control the disease.
Huiling Xu, Yanli Wang, Guangwei Han, Weihuan Fang, Fang He   +4 more
doaj   +1 more source

Correlation of the virulence of CSFV with evolutionary patterns of E2 glycoprotein

Frontiers in Bioscience, 2010
Infection with classical swine fever virus (CSFV) is costly to the livestock industry. Several genomic sequences including velogenic strains and low virulent strains have been identified. However, the reasons for the virulence of the virus have remained unclear.
Zhiyin, Wu, Qin, Wang, Qian, Feng, Yingying, Liu, Junlin, Teng, Albert Cheunghai, Yu, Jianguo, Chen   +6 more
openaire   +2 more sources

mTORC1 Negatively Regulates the Replication of Classical Swine Fever Virus Through Autophagy and IRES-Dependent Translation

iScience, 2018
Summary: Classical swine fever virus (CSFV) can utilize diverse host signaling pathways for its replication; however, the cross talk between mammalian target of rapamycin (mTOR) and CSFV remains unknown.
Qinghua Luo, Li Zhang, Feng Wei, Qiang Fang, Fei Bao, Shijiang Mi, Nan Li, Chengming Wang, Yan Liu, Changchun Tu   +9 more
doaj   +1 more source

Functionality of Chimeric E2 Glycoproteins of BVDV and CSFV in Virus Replication

Virology: Research and Treatment, 2008
An intriguing difference between the E2 glycoprotein of CSFV and the other groups of pestiviruses (nonCSFV) is a lack of two cysteine residues on positions cysteine 751 and 798. Other groups of pestivirus are not restricted to one species as swine, whereas CSFV is restricted to swine and wild boar. We constructed chimeric CSFV/BVDV E2 genes based on a
van Gennip, H.G.P., Miedema, G.K.W., Moormann, R.J.M., van Rijn, P.A.   +3 more
openaire   +2 more sources

Epidemiological analysis, risk factors, and spatial-temporal clustering of classical swine fever virus in China

Porcine Health Management
Background Classical Swine Fever (CSF), or swine cholera, is a highly acute, febrile, and contagious disease caused by the Classical Swine Fever virus (CSFV) in pigs.
Wenchao Gao, Qingyuan Liu, Jiansheng Zhou, Xiaoxue Jiang, Qing Wang, Yuntong Shi, Xiaomin Liu, Xia Liu, Lili Wu, Qin Zhao, Xiaowen Li   +10 more
doaj   +1 more source

In vitro inhibition of CSFV replication by retroviral vector-mediated RNA interference

Journal of Virological Methods, 2010
Classical swine fever (CSF) is a highly contagious viral disease of pigs which causes major economic losses worldwide. No specific drug is currently available for the effective treatment of CSFV infection. RNA interference (RNAi) technology depends on effective delivery systems, for which several effective vectors have recently been developed.
Li, Jiangnan, Guo, Huancheng, Shi, Zixue, Tu, Changchun   +3 more
openaire   +2 more sources