Results 111 to 120 of about 714,192 (184)

Conditions and timing for the precipitation of early marine diagenetic dolomite in the Triassic Dolomia Principale (northern Italy)

Sedimentology, EarlyView.
ABSTRACT Thermodynamic constraints and empirical evidence often suggest that fabric‐retentive replacement dolomites are stable carbonate minerals that preserve ancient seawater properties. This study evaluates this hypothesis by examining the Upper Triassic Dolomia Principale in Northern Italy.
Vivien Folliot, Giovanna Della Porta, Mathias Mueller, Fabrizio Berra, Benjamin F. Walter, Aratz Beranoaguirre, Sylvia Riechelmann, Oskar Schramm, Adrian Immenhauser   +8 more
wiley   +1 more source

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, Volume 159, Issue 10, Page 2393-2402, 15 November 2026.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1250-1254, November 2026.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Dimensional Analysis and Design of Dual-Scale Hexagonal Microfluidic Array Chips for High-Efficiency Capture of CTCS and CTC Clusters

Circulating tumor cells (CTCs) and CTC clusters are critical biomarkers for cancer metastasis, with clusters exhibiting 23-50 times higher metastatic potential despite comprising only 2−5% of CTCs.
KE, Zongqin, MA, Shuo, LEE, Yi-Kuen, FANG, Sile, TAVAKKOLI, Hadi   +4 more
core   +1 more source

Perspective on Circulating Tumor Cell Clusters: Why It Takes a Village to Metastasize

, 2018
Circulating tumor cell (CTC) clusters may represent one of the key mechanisms initiating the metastasis process. However, the series of pathophysiologic events by which CTC clusters originate, enter the circulation, and reach the distant sites remain to ...
Anum Shaikh, Sabino De Placido, Xiang H. Zhang, Grazia Arpino, Massimo Cristofanilli, Hin Ching Lo, Meghana V. Trivedi, Mario Giuliano, Rachel Schiff   +8 more
core   +1 more source

Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Nature Communications
Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. Here, combining computational ranking and functional determination, we identify the transmembrane protein Plexin-B2 (
Emma Schuster, Nurmaa K. Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D. Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R. Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F. Almubarak, Valery Adorno-Cruz, David P. Sullivan, Carolina Reduzzi, Allegra C. Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P. Siziopikou, Leonidas C. Platanias, Ami Shah, William A. Muller, William J. Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu   +31 more
doaj   +1 more source

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Pre-treatment Circulating Tumor Cell Associated White Blood Cell Clusters Independently Predict Poor Survival in Patients with Extensive-disease Small Cell Lung Cancer

Biomarker Insights
Background: Patients with extensive disease (ED)-small cell lung cancer (SCLC) commonly suffer a more inferior prognosis than those with limited disease (LD)-SCLC.
Ying Wang, Minghang Zhang, Cen Chen, Yanxia Liu, Yuan Gao, Hongxia Li, Baohua Lu, Mingming Hu, Hongmei Zhang, Peter Ping Lin, Zhanliang Ren, Tongmei Zhang, Shaofa Xu   +12 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source