Results 31 to 40 of about 120,218 (287)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Immune Checkpoint Inhibitor Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, Accepted Article.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W Cannon, Brian C Sauer, Jorge Rojas, Gregory J Stoddard, Gary A Kunkel, Jessica A. Walsh, Bryant R England, Joshua F Baker, Tawnie J Braaten   +9 more
wiley   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION

Annual Review of Immunology, 2006
Within the paradigm of the two-signal model of lymphocyte activation, the interest in costimulation has witnessed a remarkable emergence in the past few years with the discovery of a large array of molecules that can serve this role, including some with an inhibitory function.
Teft, Wendy A., Kirchhof, Mark G., Madrenas, Joaquín   +2 more
openaire   +3 more sources

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell [PDF]

, 2012
During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which
A. Hoffmann, Bachmann, Bachmann, Bachmann, Bannard, Camargo, Chai, Choi, Cretney, D. T. Fearon, Dong, Feau, Gong, H. Lingel, Harrington, Hegel, J. E. D. Thaventhiran, Kalia, Kallies, Katagiri, Khanna, Kwon, L. Magiera, Lee, M. Brunner-Weinzierl, M. de la Roche, Nishioka, Pearce, Pipkin, Rao, Russ, Rutishauser, Sabatos, Schlegelmilch, Sun, Taylor, Turner, Voehringer, Waterhouse, Williams, Yeo, Zhao, Zhou   +42 more
core   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity [PDF]

, 2023
Paul T. Kennedy, Emma Saulters, Andrew D. Duckworth, Yeong Jer Lim, John F. Woolley, Joseph R. Slupsky, Mark S. Cragg, Frank J. Ward, Lekh N. Dahal   +8 more
openalex   +1 more source

Polymorphism analysis of the CTLA-4 (rs231775) gene as a marker of inhibitor development in Iranian patients with hemophilia A [PDF]

, 2018
Background: Development of factor VIII (FVIII) inhibitor is the main problem of replacement therapy in patients with hemophilia A. Recently, the correlation of polymorphisms of some genes involved in immune system has been determined with inhibitor ...
Bolhassani, Azam, Keshavarz-Norouzpour, Masoumeh, Sari, Soyar   +2 more
core   +1 more source

The Cytotoxic T Lymphocyte Antigen-4+49A/G Single Nucleotide Polymorphism Association With Visceral Leishmaniasis [PDF]

, 2014
Background: Several lines of evidence approve that innate and adaptive immunity play key roles in the defense against visceral leishmaniasis (VL).
Gomes NA, Goto H, Herwaldt BL, Linsley PS, Meinecke CK, Mohebali M, Murphy ML, Murray HW, Newlove T, Uzer E   +9 more
core   +1 more source