Results 121 to 130 of about 7,425 (214)

Copper homeostasis and cuproptosis in gynecological cancers

Frontiers in Cell and Developmental Biology
Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death.
Xiaodi Huang, Xiaodi Huang, Xiaodi Huang, Mengyi Lian, Changzhong Li, Changzhong Li, Changzhong Li   +6 more
openaire   +3 more sources

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis

Communications Biology
Cuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu, Linjing Long, Min Wang, Lianli Shen, Jianjun Hu, Huijun Tang, Shufen Feng, Xiongxiu Liu, Ying Shi, Shaohui Tang, Yanfang Chen   +10 more
doaj   +1 more source

Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Biomolecules
Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent ...
Mohammad El-Nablaway, Hany M. A. Sonpol, Yaser Hosny Ali Elewa, Mohamed A. M. Ali, Mohamed Adel, Eman Serry Zayed, Maha Alhelf, Manar A. Didamoony, Amal Fahmy Dawood, Eman M. Embaby, Khaled S. El-Bayoumi, Wesam S. El-Saeed   +11 more
doaj   +1 more source

Editorial: Neurotoxins in Alzheimer\u27s disease and other dementias [PDF]

Alzheimer\u27s disease (AD) and other dementias are neurodegenerative disorders characterized by a progressive decline in cognition and independence from activities of daily living.
Fernando, Binosha, Hascup, Kevin N., Henriques, Alexandre, Poindron, Philippe L. L.   +3 more
core   +1 more source

Editorial: Stromal and immune microenvironment in breast cancer metastasis. [PDF]

, 2022
Lu, Xin, Liu, Xia, Celià-Terrassa, Toni, Ren, Guangwen   +3 more
core   +3 more sources

Penicillamine ameliorates intestinal barrier damage in dextran sulfate sodium-induced experimental colitis mice by inhibiting cuproptosis [PDF]

BackgroundCuproptosis is a copper-dependent form of cell death. However, its role in ulcerative colitis (UC) remains unknown.AimTo investigate whether cuproptosis is involved in UC and whether penicillamine (PA) improves colitis in mice by inhibiting ...
Chen Chen, Jiaze Ma, Shuangshuang Wang, Tuo Chen, Wenwen Tang, Yang Li, Yang Li, Yimeng Ma, Yugen Chen   +8 more
core   +1 more source

Cuproptosis and its potential role in musculoskeletal disease [PDF]

Cuproptosis, a recently identified form of copper-dependent cell death, arises from intracellular copper dyshomeostasis. As an essential trace element, copper plays a critical role in bioenergetic metabolism, redox regulation, and synaptic transmission ...
Aoshuang Xu, Honglin Wang, Huiling Mei, Ji Rao, Lin Lu, Wentao Zhang, Xiaoyue Yao, Ziyang Xiang   +7 more
core   +1 more source

The role of cuproptosis in gastric cancer

Frontiers in Immunology
As a biologically essential transition metal, copper is widely involved in various enzymatic reactions and crucial biological processes in the body. It plays an increasingly important role in maintaining normal cellular metabolism and supporting the growth and development of the human body.
Yixian Li, Wenhao Sun, Shaolin Yuan, Xinxin Liu, Ziqi Zhang, Renjun Gu, Pengfei Li, Xin Gu   +7 more
openaire   +3 more sources

Emerging roles of cuproptosis in liver diseases

Digestive and Liver Disease
Intracellular copper levels should be maintained within a controlled range to obtain copper homeostasis. Cuproptosis, a newly discovered form of cell death, occurs when excessive copper ions bind to the lipoylated enzymes in the tricarboxylic acid cycle, which leads to lipoylated protein aggregation, proteotoxic stress, and ultimately cell death ...
Qi, Yang, Xiaoxuan, Liu, Huixin, Tang, Yu, Chen, Li, Bai   +4 more
openaire   +2 more sources

Cuproptosis-associated ncRNAs predict breast cancer subtypes

PLOS ONE
Background Cuproptosis is a novel copper-dependent mode of cell death that has recently been discovered. The relationship between Cuproptosis-related ncRNAs and breast cancer subtypes, however, remains to be studied. Methods The aim of this study was to construct a breast cancer subtype prediction model associated with Cuproptosis.
Qing Xia, Jinze Shen, Qurui Wang, Ruixiu Chen, Xinying Zheng, Qibin Yan, Lihua Du, Hanbing Li, Shiwei Duan   +8 more
openaire   +4 more sources