Results 71 to 80 of about 1,310,929 (245)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Narrative and inquiry as a basis for a design framework to reconnect mathematics curriculum with students

, 2018
Curriculum ergonomics focuses on the “fit” between students and the curriculum, and how this “fit” extends students’ understanding of content. We argue that the opportunity for narrative in an inquiry-based learning environment in mathematics promotes ...
Ali, Muhammad, Fry, Kym, Makar, Katie
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Curriculum, Empiricisms, and Post-Truth Politics [PDF]

, 2019
The purpose of this paper is to approach the phenomenon of post-Truth politics as an important site of inquiry for the field of curriculum theory. The authors define curriculum as the empirical frameworks that shape our acts of knowing, being, and ...
Franklin-Phipps, Asilia, Gleason, Tristan   +1 more
core   +1 more source

Information literacy for inquiry-based learning

Transinformação
Given the importance of focus on globalized curriculum, this study presents a review of the literature on issues related to the nature of learning contents and curriculum, especially the development of curriculum based on the research process - inquiry ...
Kelley Cristine Gonçalves Dias GASQUE
doaj   +1 more source

Inquiry Objectives in Curriculum Development

The American Biology Teacher, 1970
There has been, over the past 13; vpars, a welldocumented renewal of interest in the concept of educational objectives. If this period has accomplished anything new and different, it has been in redefining the rules and principles governing the structure of objective statements.
openaire   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

The Emergence of Narrative and the Discovery of Humanism

Critical Education
This paper returns to the roots of European Humanism to rediscover the moral and political base for contemporary narrative inquiry. A brief analytical review is conducted of forms of artistic representation from C15th/C16th Florentine painting to reveal ...
Saville Kushner
doaj   +1 more source

Effects of Inquiry-based Learning on Students’ Science Literacy Skills and Confidence

International Journal for the Scholarship of Teaching and Learning, 2009
Calls for reform in university education have prompted a movement from teacher- to student-centered course design, and included developments such as peer-teaching, problem and inquiry-based learning.
Cara Gormally, Peggy Brickman, Brittan Hallar, Norris Armstrong   +3 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source