Results 201 to 210 of about 42,965 (221)
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CXCL12-γ expression is inhibited in neuroinflammation
Brain Research, 2013CXCL12 plays a protective role in CNS autoimmunity. Expression of CXCL12-γ, which has distinct structural and functional properties than the other isoforms of CXCL12, was determined in spinal cords of rats immunized to develop experimental autoimmune encephalomyelitis (EAE).
Timotijević, Gordana S +5 more
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CXCL12 and CXCR4 in bone marrow physiology
Expert Review of Hematology, 2010This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis.
Natalia M, Moll, Richard M, Ransohoff
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Nitric oxide inhibits CXCL12 expression in neuroinflammation
Immunology & Cell Biology, 2013Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of inflammatory and demyelinating disease of the CNS, multiple sclerosis (MS). Nitric oxide (NO), by contrast, predominantly contributes to
Petković, Filip +4 more
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Pathological roles of the homeostatic chemokine CXCL12
Cytokine & Growth Factor Reviews, 2018CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various ...
Rik, Janssens +2 more
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CXCR7, CXCR4 and CXCL12: An eccentric trio?
Journal of Neuroimmunology, 2008CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
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CXCL12/CXCR4 signalling in neuronal cell migration
Current Opinion in Neurobiology, 2008The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in the immune system. However, over the past years it has become clear that this receptor/ligand pair is an important component of the machinery that controls cell migration in different regions of the developing nervous system. Here
Tiveron, M.C., Cremer, H.
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CXCR4-CXCL12-Dependent Inflammatory Network and Endothelial Progenitors
Current Medicinal Chemistry, 2010The endothelial progenitor cells (EPCs) are angiogenic cells having properties similar to those of embryonal angioblasts. The number and function of EPCs are affected by a variety of conditions, including cytokines and chemokines, which are pivotal inflammatory signaling molecules. The purpose of this paper is to review current knowledge about the role
SALVATORE, PAOLA +3 more
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ความสำคัญและที่มาปัญหาการวิจัย : 14-40% ผู้ป่วยมะเร็งปอดชนิดไม่เล็กระยะลุกลามจะเกิดมะเร็งกระจายไปที่กระดูกและประมาณครึ่งหนึ่งจะเกิดภาวะแทรกซ้อนตามมา (1) ซึ่งมีผลต่อคุณภาพชีวิตและอัตราการรอดชีวิตที่ 2 ปี เท่ากับ 11.3%(2) ถึงแม้ว่าการทำ Bone scan และ FDG-PET จะมีความไวและความจำเพาะที่สูง แต่ก็ยังพบว่ามีผลลบและผลบวกลวงได้ในชนิดมะเร็งที่มีการกัดกร่อนท ...
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Glioblastomas: Role of CXCL12 Chemokine
2010Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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CXCR4/CXCL12 as a Therapeutic Target
2014The interaction of acute myeloid leukemia (AML) blasts with the bone marrow microenvironment regulates critical processes important in sustaining the malignant clone including self-renewal, cell growth, and proliferation as well as resistance to chemotherapy.
Geoffrey L. Uy, John F. DiPersio
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