Results 221 to 230 of about 76,809 (334)

The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes [PDF]

, 2005
Karl Balabanian, Bernard Lagane, Simona Infantino, Ken Y.C. Chow, Julie Harriague, Barbara Moepps, Fernando Arenzana‐Seisdedos, Marcus Thelen, Françoise Bachelerie   +8 more
openalex   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases. [PDF]

Arthritis Res Ther
Ruths L, de Hesselle H, Haußner F, Albers S, Harms M, Freitag T, Münch J, Riegger J.   +7 more
europepmc   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Integrative Transcriptomic and Machine Learning Analysis Identifies Key Senescence-Associated Secretory Phenotype Genes Associated With Immune Dysregulation in Periodontitis. [PDF]

Hum Mutat
Zeng J, Huang J, He J, Tan J, Duan M, Song Y, Yang L.   +6 more
europepmc   +1 more source

Data from The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Heregulin β1 and CXCL12

, 2023
Lorena Hernandez, Tatiana Smirnova, Dmitriy Kedrin, Jeffrey Wyckoff, Liyin Zhu, E. Richard Stanley, Dianne Cox, William J. Muller, Jeffrey W. Pollard, Nico van Rooijen, Jeffrey E. Segall   +10 more
openalex   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis. [PDF]

Sci Rep
Zhang L, Lv Y, Du Z, Chen J, Mo P, Xu X, Sun H, Yan Y, Zhu C, Huang L, Hao C, Zhou X, Dong H, Chen Z.   +13 more
europepmc   +1 more source

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways [PDF]

, 2011
Luke Drury, Joshua J. Ziarek, Stéphanie Gravel, Christopher T. Veldkamp, Tomonori Takekoshi, Samuel Hwang, Nikolaus Heveker, Brian F. Volkman, Michael B. Dwinell   +8 more
openalex   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source