Results 121 to 130 of about 10,590 (201)
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]
, 2014 The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba +72 more
core +3 more sources
CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation
PLOS ONE, 2016 Differentiation of oligodendroglial precursor cells (OPCs), a crucial prerequisite for central nervous system (CNS) remyelination in diseases such as Multiple Sclerosis (MS), is modulated by a multitude of extrinsic and intrinsic factors. In a previous study we revealed that the chemokine CXCL12 stimulates rodent OPC differentiation via activation of ...
Kremer, David +6 more
openaire +5 more sources
Stem Cell Research, 2017 CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adrenergic
Delaine K. Ceholski +10 more
doaj +1 more source
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis:Emerging Roles in Bone Metastasis [PDF]
, 2018 Bone metastasis is the most advanced stage of many cancers and indicates a poor prognosis for patients due to resistance to anti-tumor therapies. The establishment of metastasis within the bone is a multistep process.
Graham, Nicola, Qian, Bin-Zhi
core +2 more sources
The role of chemokine receptor CXCR7 in lung cancer
Clinical Oncology and Cancer Research, 2010 OBJECTIVE To investigate whether CXCL12 and its receptor, CXCR7, play a role in lung cancer invasion and metastasis.METHODS Western blot and immunocytochemistry were used to detect CXCR7 protein expression in 8 lung cancer cell lines, EKVX, HOP62, HOP92, NCI-H23, NCI-H226, NCI-H322M, NCI-H446, and A549, and cell migration experiment was conducted to ...
Jun LIU +3 more
openaire +2 more sources
Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis [PDF]
Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow.
Asri, Amir +3 more
core +1 more source
Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7
Clinical and Developmental Immunology, 2013 In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated.
Shipeng Dang +14 more
doaj +1 more source
Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer
Molecular Oncology, 2018 Ovarian cancer (OC) is one of the most intractable diseases, exhibiting tremendous molecular heterogeneity and lacking reliable methods for screening, resulting in late diagnosis and widespread peritoneal dissemination.
Samira Benhadjeba +4 more
doaj +1 more source
Structural studies on the CXCR7 decoy receptor
EMBnet.journal, 2012 Motivations. Recent studies have revealed that the chemokine receptor CXCR7 plays an important role in cancer development. However, little is known about the effect of CXCR7 on the process of hepatocellular carcinoma (HCC) cell invasion and angiogenesis. In particular, CXCR7 was overexpressed in HCC tissues.
T De Vero, S Costantini, G Colonna
openaire +2 more sources
Localization and Trafficking of CXCR4 and CXCR7
, 2022 G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins, and are the master components that translate extracellular stimulus into intracellular signaling, which in turn modulates key physiological and pathophysiological processes.
openaire +1 more source