Results 121 to 130 of about 10,559 (201)

Intracellular coexpression of CXC- and CC– chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation [PDF]

, 2014
BackgroundChemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesion and survival.MethodsIn this study
A Ben-Baruch, A Ludwig, A Muller, A Richmond, AG Yang, AJ Carlisle, Alicia Martínez-Romero, C Dong, C Monteagudo, C Monteagudo, Carlos Monteagudo, CM Tan, E Lee, E Lázár-Molnár, EC Finger, EM Borroni, FM Speetjens, FR Balkwill, FR Balkwill, G Brooke, H Kulbe, H Li, H Yasuoka, IK Na, J Meijer, J Vandercappellen, JE O’Connor, JG Cyster, JM Burns, José-Enrique O’Connor, K Kawada, K Schaeuble, L Achour, Liria Terrádez, M Chartrain, M Herlyn, M Notohamiprodjo, M Perego, MI Longo-Imedio, MM Robledo, MT Drake, N Onai, O Shakhova, O Simonetti, PA Cronin, PS Steeg, R Gil-Benso, Robert C Callaghan, Rosario Gil-Benso, S Shimizu, Sandra Pinto, SJ Allen, SW Kim, T Kakinuma, T Murakami, T Schatton, Teresa San-Miguel, X Bai, X Sun, Y Xi   +59 more
core   +1 more source

Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross-sectional study [PDF]

, 2013
INTRODUCTION: IL-10--producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce immunological tolerance and, in turn, to inhibit the pathogenesis of autoimmune ...
Gabriela Hernández-Molina, Guadalupe Lima, Janette Furuzawa-Carballeda, Karen Férez-Blando, Luis Llorente, Yahaira Rivera-Vicencio   +5 more
core   +1 more source

CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response

Stem Cell Research, 2017
CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adrenergic
Delaine K. Ceholski, Irene C. Turnbull, Venu Pothula, Laura Lecce, Andrew A. Jarrah, Changwon Kho, Ahyoung Lee, Lahouaria Hadri, Kevin D. Costa, Roger J. Hajjar, Sima T. Tarzami   +10 more
doaj   +1 more source

Gene expression profiling of Ewing sarcoma tumours reveals the prognostic importance of tumour–stromal interactions: a report from the Children's Oncology Group [PDF]

, 2015
Relapse of Ewing sarcoma (ES) can occur months or years after initial remission, and salvage therapy for relapsed disease is usually ineffective. Thus, there is great need to develop biomarkers that can predict which patients are at risk for relapse so ...
Abdel-Wahab, Asgharzadeh, Balamuth, Benjamini, Bennani-Baiti, Berghuis, Bishop, Bishop, Borinstein, Breiman, Carlson, Cleaver, Cooper, Cortes, Crompton, Davicioni, Deley, Doorninck, Erho, Figueroa, Ginsberg, Hamdan, Huang, Janitza, Jin, Johnson, Kalbfleisch, Kang, Krook, Kuhn, Lockstone, Luo, Marino-Enriquez, Mendoza-Naranjo, Missiaglia, Oberthuer, Ohali, Paulussen, Peter, Schaefer, Scotlandi, Shieh, Shukla, Smyth, Specht, Starmans, Stricker, Trinquand, Wilkerson, Wilson, Womer, Youn   +51 more
core   +1 more source

The role of chemokine receptor CXCR7 in lung cancer

Clinical Oncology and Cancer Research, 2010
OBJECTIVE To investigate whether CXCL12 and its receptor, CXCR7, play a role in lung cancer invasion and metastasis.METHODS Western blot and immunocytochemistry were used to detect CXCR7 protein expression in 8 lung cancer cell lines, EKVX, HOP62, HOP92, NCI-H23, NCI-H226, NCI-H322M, NCI-H446, and A549, and cell migration experiment was conducted to ...
Jun LIU, Fu-rong ZHANG, Yue LI, Chang-li WANG   +3 more
openaire   +2 more sources

Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7

Clinical and Developmental Immunology, 2013
In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated.
Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu   +14 more
doaj   +1 more source

Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer

Molecular Oncology, 2018
Ovarian cancer (OC) is one of the most intractable diseases, exhibiting tremendous molecular heterogeneity and lacking reliable methods for screening, resulting in late diagnosis and widespread peritoneal dissemination.
Samira Benhadjeba, Lydia Edjekouane, Karine Sauvé, Euridice Carmona, André Tremblay   +4 more
doaj   +1 more source

Structural studies on the CXCR7 decoy receptor

EMBnet.journal, 2012
Motivations. Recent studies have revealed that the chemokine receptor CXCR7 plays an important role in cancer development. However, little is known about the effect of CXCR7 on the process of hepatocellular carcinoma (HCC) cell invasion and angiogenesis. In particular, CXCR7 was overexpressed in HCC tissues.
T De Vero, S Costantini, G Colonna
openaire   +2 more sources

Localization and Trafficking of CXCR4 and CXCR7

, 2022
G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins, and are the master components that translate extracellular stimulus into intracellular signaling, which in turn modulates key physiological and pathophysiological processes.
openaire   +1 more source

A patent review of CXCR7 modulators (2019-present)

Expert Opinion on Therapeutic Patents
Atypical chemokine receptor 3 (ACKR3) (formerly CXCR7) regulates various biological processes through its ligands and is closely associated with numerous diseases, including inflammation, cancer, cardiovascular diseases (CVDs), pain, and neurological disorders.
Thanigaimalai Pillaiyar, Stefan Laufer
openaire   +2 more sources