Results 121 to 130 of about 10,649 (214)
AI-assisted models to predict chemotherapy drugs modified with C60 fullerene derivatives. [PDF]
Beilstein J NanotechnolEmploying quantitative structure–activity relationship (QSAR)/ quantitative structure–property relationship (QSPR) models, this study explores the application of fullerene derivatives as nanocarriers for breast cancer chemotherapy drugs.
Robles-Hernández JS +5 more
europepmc +2 more sources
Stem Cell Research, 2017 CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adrenergic
Delaine K. Ceholski +10 more
doaj +1 more source
The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]
, 2018 Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella +5 more
core +1 more source
Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system [PDF]
, 2014 The proper functioning of the dopaminergic system requires the coordinated formation of projections extending from dopaminergic neurons in the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field to a wide array of forebrain targets ...
Abe, Philipp +7 more
core +1 more source
The role of chemokine receptor CXCR7 in lung cancer
Clinical Oncology and Cancer Research, 2010 OBJECTIVE To investigate whether CXCL12 and its receptor, CXCR7, play a role in lung cancer invasion and metastasis.METHODS Western blot and immunocytochemistry were used to detect CXCR7 protein expression in 8 lung cancer cell lines, EKVX, HOP62, HOP92, NCI-H23, NCI-H226, NCI-H322M, NCI-H446, and A549, and cell migration experiment was conducted to ...
Jun LIU +3 more
openaire +2 more sources
Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7
Clinical and Developmental Immunology, 2013 In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated.
Shipeng Dang +14 more
doaj +1 more source
Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer
Molecular Oncology, 2018 Ovarian cancer (OC) is one of the most intractable diseases, exhibiting tremendous molecular heterogeneity and lacking reliable methods for screening, resulting in late diagnosis and widespread peritoneal dissemination.
Samira Benhadjeba +4 more
doaj +1 more source
Structural studies on the CXCR7 decoy receptor
EMBnet.journal, 2012 Motivations. Recent studies have revealed that the chemokine receptor CXCR7 plays an important role in cancer development. However, little is known about the effect of CXCR7 on the process of hepatocellular carcinoma (HCC) cell invasion and angiogenesis. In particular, CXCR7 was overexpressed in HCC tissues.
T De Vero, S Costantini, G Colonna
openaire +2 more sources
Localization and Trafficking of CXCR4 and CXCR7
, 2022 G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins, and are the master components that translate extracellular stimulus into intracellular signaling, which in turn modulates key physiological and pathophysiological processes.
openaire +1 more source
A patent review of CXCR7 modulators (2019-present)
Expert Opinion on Therapeutic PatentsAtypical chemokine receptor 3 (ACKR3) (formerly CXCR7) regulates various biological processes through its ligands and is closely associated with numerous diseases, including inflammation, cancer, cardiovascular diseases (CVDs), pain, and neurological disorders.
Thanigaimalai Pillaiyar, Stefan Laufer
openaire +2 more sources