Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Farahani H +4 more
europepmc +1 more source
Macrophage migration inhibitory factor: Exploring physiological roles and comparing health benefits against oncogenic and autoimmune risks (Review). [PDF]
Camacho Meza G +5 more
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Attract to kill: Exploring the potential of motility trapping as a novel treatment strategy for high-grade gliomas. [PDF]
Bamelis AS +6 more
europepmc +1 more source
LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses. [PDF]
Sindram E +18 more
europepmc +1 more source
Dual targeting of CXCR4 and EZH2 in endometriosis. [PDF]
Brunty S +5 more
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Chemokines and their receptors in the esophageal carcinoma tumor microenvironment: key factors for metastasis and progression. [PDF]
Liu P, Sun Z.
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Advances in CXCR7 Modulators [PDF]
CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12).
Nicole Lounsbury
exaly +5 more sources
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Resonating with the signaling bias of CXCR7
Molecular Cell, 2022Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.
Parishmita, Sarma, Arun K, Shukla
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CXCR7, CXCR4 and CXCL12: An eccentric trio?
Journal of Neuroimmunology, 2008CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
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