Results 181 to 190 of about 6,662 (210)

Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes

Cellular and Molecular Neurobiology, 2012
We previously demonstrated that in astrocytes, SDF-1/CXCL12 exclusively signals through CXCR7 despite the additional presence of the alternate SDF-1/CXCL12 receptor, CXCR4. In addition, we provided evidence that astrocytic CXCR7-signalling involves a G protein-dependent mechanism.
Jana, Lipfert, Veysel, Ödemis, Jürgen, Engele   +2 more
openaire   +2 more sources

SDF‐1α induces differential trafficking of CXCR4‐CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival

The FASEB Journal, 2014
ABSTRACT Platelet‐derived SDF‐1α (CXCL12) mediates inflammatory and regenerative mechanisms. The present study characterizes the effect of SDF‐1α ligation in platelets. SDF‐1α (0–100 μM) dose and time dependently caused internalization of its receptor CXCR4 (28.9±1.6 vs . 16.
Chatterjee, Madhumita, Seizer, Peter, Borst, Oliver, Mack, Andreas F., Geisler, Tobias, Langer, Harald, May, Andreas E., Vogel, Sebastian, Lang, Florian, Gawaz, Meinrad Paul, Schönberger, Tanja   +10 more
openaire   +3 more sources

Chewing the fat on platelet CXCR7

Blood, 2022
Hannah, Stevens, James D, McFadyen
openaire   +2 more sources

Estrogen represses CXCR7 gene expression by inhibiting the recruitment of NFκB transcription factor at the CXCR7 promoter in breast cancer cells

Biochemical and Biophysical Research Communications, 2013
Although many studies reported mechanisms involved in the positive regulation of estrogens (E2) target genes, very little is known concerning the repressive effect of E2. In this study, we explored the molecular mechanisms by which E2 regulates CXCR7 expression in breast cancer cells. Our results show that E2-mediated down-regulation of CXCR7 occurs at
Kerdivel, Gwenneg, Boudot, Antoine, Pakdel, Farzad   +2 more
openaire   +2 more sources

Chemokine receptor CXCR7 is an independent prognostic biomarker in glioblastoma

Cancer Biomarkers, 2017
BACKGROUND: Glioblastoma (GBM) is the most common and most fatal primary brain cancer in adults. Due to the complex nature of GBM, its pathogenesis still remain unclear. Accumulating evidence suggest that chemokine receptor CXCR7 contribute to the development of various types of tumors.
Lina, Deng, Wenxin, Zheng, Xueshuang, Dong, Jianghua, Liu, Chunyu, Zhu, Dan, Lu, Jin, Zhang, Laijun, Song, Yuchao, Wang, Dan, Deng   +9 more
openaire   +2 more sources

CXCR7 mediates angiogenesis in human glioma

2013
64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Guentchev, M, Tchorbanov, A, Birner, P, Tuettenberg, J   +3 more
openaire   +1 more source

Expressions of CXCR7/ligands may be involved in oral carcinogenesis

Journal of Molecular Histology, 2011
Oral carcinogenesis is a multistep process and requires accumulation and interplay of a series of molecular events. Chemokines and their receptors have been suggested to play important roles in the initiation or progression of cancers. Until now, no report focuses on their alterations in premalignant stage of oral squamous cell carcinoma (OSCC ...
Juan, Xia, Juan, Wang, Na, Chen, Yaohui, Dai, Yun, Hong, Xiaobing, Chen, Bin, Cheng   +6 more
openaire   +2 more sources

Nonspecific CXCR7 antibodies

Immunology Letters, 2010
Robert D, Berahovich, Mark E T, Penfold, Thomas J, Schall   +2 more
openaire   +2 more sources

Synthesis of a CXCR7 Modulator

Synfacts, 2018
openaire   +1 more source

Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma

Endocrine Pathology, 2012
Zhen Liu
exaly