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Roles of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway in Oncovirus Infection and Virus-Associated Cancers. [PDF]
VirusesFan J, Ryu V, Qin Z, Dai L.
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Chemokines as therapeutic targets for multiple sclerosis: a spatial and chronological perspective. [PDF]
Front ImmunolArimitsu NN +4 more
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CXCL12 no hatsugen wa shokudo henpei johigan no zoshoku o sokushinshi, yogo o akkasaseru [PDF]
Uchi, Yusuke +2 more
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Resonating with the signaling bias of CXCR7
Molecular Cell, 2022Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.
Parishmita, Sarma, Arun K, Shukla
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CXCR7, CXCR4 and CXCL12: An eccentric trio?
Journal of Neuroimmunology, 2008CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
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Science Signaling, 2011
CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways.
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CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways.
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The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
Molecular Cancer, 2011 Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands
Jaén Juan C +4 more
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The FASEB Journal, 2014
ABSTRACT Platelet‐derived SDF‐1α (CXCL12) mediates inflammatory and regenerative mechanisms. The present study characterizes the effect of SDF‐1α ligation in platelets. SDF‐1α (0–100 μM) dose and time dependently caused internalization of its receptor CXCR4 (28.9±1.6 vs . 16.
Chatterjee, Madhumita +10 more
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ABSTRACT Platelet‐derived SDF‐1α (CXCL12) mediates inflammatory and regenerative mechanisms. The present study characterizes the effect of SDF‐1α ligation in platelets. SDF‐1α (0–100 μM) dose and time dependently caused internalization of its receptor CXCR4 (28.9±1.6 vs . 16.
Chatterjee, Madhumita +10 more
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Atorvastatin inhibits CXCR7 induction to reduce macrophage migration
Biochemical Pharmacology, 2014We have recently reported that CXCR7, the alternate high affinity SDF-1 receptor, is induced during monocyte-to-macrophage differentiation, leading to increased macrophage phagocytosis linked to atherosclerosis. Statins, the most widely used medications for atherosclerosis, were shown to have pleiotropic beneficial effects independent of their ...
Wanshu, Ma +5 more
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Activation of CXCR7 receptor promotes oligodendroglial cell maturation
Annals of Neurology, 2010AbstractObjective:Differentiation of oligodendroglial precursor cells is crucial for central nervous system (re)myelination and is influenced by multiple extrinsic and intrinsic factors. Chemokines, a group of small proteins, are highly conserved among mammals and have been implicated in a variety of biological processes during development, tissue ...
Peter, Göttle +6 more
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