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Drug Design Targeting the CXCR4/CXCR7/CXCL12 Pathway
Current Topics in Medicinal Chemistry, 2016Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as tumor-associated blood vessels, although the level of CXCR7 in normal blood cells is low. Recently, many studies
Dongsheng, Xu +4 more
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Chewing the fat on platelet CXCR7
Blood, 2022Hannah, Stevens, James D, McFadyen
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Differential Expression of RDC1/CXCR7 in the Human Placenta
Journal of Clinical Immunology, 2008Chemokine receptor expression by human trophoblast and other placental cells have important implications for understanding the regulation of placental growth, development, and their role in maternofetal HIV transmission. CXCR7, now a deorphanized G protein coupled receptor that has been recently shown to bind to the ligands ITAC and CXCL12 has been ...
Vishwas, Tripathi +5 more
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CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies
International Journal of Molecular Sciences, 2021Marc Bissonnette
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The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
Frontiers in Pharmacology, 2020David J Riese Ii, Jianzhong Shen
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The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
Molecular Cancer, 2014Nicole Salazar +2 more
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