Results 171 to 180 of about 6,925 (209)

Differential Expression of RDC1/CXCR7 in the Human Placenta

Journal of Clinical Immunology, 2008
Chemokine receptor expression by human trophoblast and other placental cells have important implications for understanding the regulation of placental growth, development, and their role in maternofetal HIV transmission. CXCR7, now a deorphanized G protein coupled receptor that has been recently shown to bind to the ligands ITAC and CXCL12 has been ...
Vishwas, Tripathi, Romsha, Verma, Amit, Dinda, Neena, Malhotra, Jagdeep, Kaur, Kalpana, Luthra   +5 more
openaire   +2 more sources

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

Molecular Pharmacology, 2009
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that AMD3100 also binds to the alternative CXCL12 receptor CXCR7. CXCL12 or AMD3100 alone activate beta-arrestin recruitment to CXCR7, which we identify as a previously unreported signaling pathway of CXCR7.
Irina, Kalatskaya, Yamina A, Berchiche, Stéphanie, Gravel, Brian J, Limberg, Jan S, Rosenbaum, Nikolaus, Heveker   +5 more
openaire   +2 more sources

Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes

Cellular and Molecular Neurobiology, 2012
We previously demonstrated that in astrocytes, SDF-1/CXCL12 exclusively signals through CXCR7 despite the additional presence of the alternate SDF-1/CXCL12 receptor, CXCR4. In addition, we provided evidence that astrocytic CXCR7-signalling involves a G protein-dependent mechanism.
Jana, Lipfert, Veysel, Ödemis, Jürgen, Engele   +2 more
openaire   +2 more sources

Chewing the fat on platelet CXCR7

Blood, 2022
Hannah, Stevens, James D, McFadyen
openaire   +2 more sources

SDF‐1α induces differential trafficking of CXCR4‐CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival

The FASEB Journal, 2014
ABSTRACT Platelet‐derived SDF‐1α (CXCL12) mediates inflammatory and regenerative mechanisms. The present study characterizes the effect of SDF‐1α ligation in platelets. SDF‐1α (0–100 μM) dose and time dependently caused internalization of its receptor CXCR4 (28.9±1.6 vs . 16.
Chatterjee, Madhumita, Seizer, Peter, Borst, Oliver, Mack, Andreas F., Geisler, Tobias, Langer, Harald, May, Andreas E., Vogel, Sebastian, Lang, Florian, Gawaz, Meinrad Paul, Schönberger, Tanja   +10 more
openaire   +3 more sources

CXCR7 mediates angiogenesis in human glioma

2013
64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Guentchev, M, Tchorbanov, A, Birner, P, Tuettenberg, J   +3 more
openaire   +1 more source

Nonspecific CXCR7 antibodies

Immunology Letters, 2010
Robert D, Berahovich, Mark E T, Penfold, Thomas J, Schall   +2 more
openaire   +2 more sources

CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies

International Journal of Molecular Sciences, 2021
Marc Bissonnette, Bissonnette Marc
exaly  

CXCR7 agonists inhibit the function of CXCL12 by down-regulation of CXCR4

Biochemical and Biophysical Research Communications, 2013
Toshihiro Nanki, Shinobu Suzuki
exaly  

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

European Journal of Medicinal Chemistry, 2012
Maikel Wijtmans, C De Graaf, Meritxell Canals   +2 more
exaly