Results 171 to 180 of about 6,662 (210)

Engineering MSC Migration: Roles of Nanoparticles in Activating Migratory Pathways and Functions. [PDF]

Int J Mol Sci
Batsaikhan T, Lee HS, Seo YJ.
europepmc   +1 more source

CXCR7 promotes pulmonary vascular remodeling via targeting p38/MMP2 pathway in pulmonary arterial hypertension. [PDF]

J Thorac Dis
Xu J, Miao S, Wu T, Hu C, Huang D, Zhang X.   +5 more
europepmc   +1 more source

The effect of CXCL12 on survival outcomes of patients with viral hepatitis-associated hepatocellular carcinoma after hepatectomy. [PDF]

Heliyon
Lu Y, Xing F, Peng S.
europepmc   +1 more source

The Use of Biologics for Targeting GPCRs in Metastatic Cancers. [PDF]

BioTech (Basel)
McBrien C, O'Connell DJ.
europepmc   +1 more source

Chemokine Receptors CXCR3 and CXCR7

, 2012
openaire   +1 more source

Shifting Signals with CXCR7

Science Signaling, 2011
CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways.
Elizabeth M. Adler
openaire   +2 more sources

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Resonating with the signaling bias of CXCR7

Molecular Cell, 2022
Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.
Parishmita, Sarma, Arun K, Shukla
openaire   +2 more sources

CXCR7, CXCR4 and CXCL12: An eccentric trio?

Journal of Neuroimmunology, 2008
CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
openaire   +2 more sources

Differential Expression of RDC1/CXCR7 in the Human Placenta

Journal of Clinical Immunology, 2008
Chemokine receptor expression by human trophoblast and other placental cells have important implications for understanding the regulation of placental growth, development, and their role in maternofetal HIV transmission. CXCR7, now a deorphanized G protein coupled receptor that has been recently shown to bind to the ligands ITAC and CXCL12 has been ...
Vishwas, Tripathi, Romsha, Verma, Amit, Dinda, Neena, Malhotra, Jagdeep, Kaur, Kalpana, Luthra   +5 more
openaire   +2 more sources

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

Molecular Pharmacology, 2009
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that AMD3100 also binds to the alternative CXCL12 receptor CXCR7. CXCL12 or AMD3100 alone activate beta-arrestin recruitment to CXCR7, which we identify as a previously unreported signaling pathway of CXCR7.
Irina, Kalatskaya, Yamina A, Berchiche, Stéphanie, Gravel, Brian J, Limberg, Jan S, Rosenbaum, Nikolaus, Heveker   +5 more
openaire   +2 more sources