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Atorvastatin inhibits CXCR7 induction to reduce macrophage migration
Biochemical Pharmacology, 2014We have recently reported that CXCR7, the alternate high affinity SDF-1 receptor, is induced during monocyte-to-macrophage differentiation, leading to increased macrophage phagocytosis linked to atherosclerosis. Statins, the most widely used medications for atherosclerosis, were shown to have pleiotropic beneficial effects independent of their ...
Wanshu, Ma +5 more
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Activation of CXCR7 receptor promotes oligodendroglial cell maturation
Annals of Neurology, 2010AbstractObjective:Differentiation of oligodendroglial precursor cells is crucial for central nervous system (re)myelination and is influenced by multiple extrinsic and intrinsic factors. Chemokines, a group of small proteins, are highly conserved among mammals and have been implicated in a variety of biological processes during development, tissue ...
Peter, Göttle +6 more
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Drug Design Targeting the CXCR4/CXCR7/CXCL12 Pathway
Current Topics in Medicinal Chemistry, 2016Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as tumor-associated blood vessels, although the level of CXCR7 in normal blood cells is low. Recently, many studies
Dongsheng, Xu +4 more
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Chewing the fat on platelet CXCR7
Blood, 2022Hannah, Stevens, James D, McFadyen
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Differential Expression of RDC1/CXCR7 in the Human Placenta
Journal of Clinical Immunology, 2008Chemokine receptor expression by human trophoblast and other placental cells have important implications for understanding the regulation of placental growth, development, and their role in maternofetal HIV transmission. CXCR7, now a deorphanized G protein coupled receptor that has been recently shown to bind to the ligands ITAC and CXCL12 has been ...
Vishwas, Tripathi +5 more
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[Recent advances and applications of CXCR7].
Zhonghua bing li xue za zhi = Chinese journal of pathology, 2011Qin, Shen, Fang, Wang
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