Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? [PDF]
Frontiers in Immunology, 2020 TRPM2 is a non-selective, Ca2+-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR).
Ralf Fliegert +2 more
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Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion [PDF]
Chinese Medical Journal, 2017 Background: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown.
Yu Zou +3 more
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Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice [PDF]
Frontiers in Neuroscience, 2016 Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be ...
Jing Zhong +18 more
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Cyclic ADP Ribose Hydrolase (CD38) Inhibitors. [PDF]
ACS Med Chem Lett, 2022 Blass BE.
europepmc +4 more sources
A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death [PDF]
iScience, 2019 Summary: SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN ...
Zhi Ying Zhao +13 more
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Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+ [PDF]
Nature CommunicationsTpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Chulei Cao +17 more
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Connexin-43 hemichannels mediate cyclic ADP-ribose generation and its Ca2+-mobilizing activity by NAD+/cyclic ADP-ribose transport. [PDF]
J Biol Chem, 2011 The ADP-ribosyl cyclase CD38 whose catalytic domain resides in outside of the cell surface produces the second messenger cyclic ADP-ribose (cADPR) from NAD(+). cADPR increases intracellular Ca(2+) through the intracellular ryanodine receptor/Ca(2+) release channel (RyR). It has been known that intracellular NAD(+) approaches ecto-CD38 via its export by
Song EK +9 more
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Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. [PDF]
PLoS ONE, 2015 Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and
Alicia Cabezas +8 more
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Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise
Cells, 2022 Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose
Li Li Ji, Dongwook Yeo
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Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
Cells, 2022 NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in oxidation–reduction (redox) reactions in various energy production processes, such as the Krebs cycle, fatty acid oxidation, glycolysis and serine biosynthesis ...
Lola E. Navas, Amancio Carnero
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