Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? [PDF]
Front Immunol, 2020 TRPM2 is a non-selective, Ca2+-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR).
Fliegert R, Riekehr WM, Guse AH.
europepmc +2 more sources
Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion. [PDF]
Chin Med J (Engl), 2017 Background: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown.
Zou Y, He X, Peng QY, Guo QL.
europepmc +2 more sources
Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. [PDF]
Front Neurosci, 2016 Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be ...
Zhong J +18 more
europepmc +2 more sources
Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise
Cells, 2022 Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose
Li Li Ji, Dongwook Yeo
doaj +1 more source
Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
Cells, 2022 NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in oxidation–reduction (redox) reactions in various energy production processes, such as the Krebs cycle, fatty acid oxidation, glycolysis and serine biosynthesis ...
Lola E. Navas, Amancio Carnero
doaj +1 more source
Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD. [PDF]
Nat CommunTpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Cao C +17 more
europepmc +2 more sources
A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. [PDF]
iScience, 2019 Summary: SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN ...
Zhao ZY +13 more
europepmc +2 more sources
Emerging Concepts on the Role of ADP-Ribosylation
Challenges, 2020 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
doaj +1 more source
Molecular Brain, 2021 Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory.
Yoonjeong Jeon +3 more
doaj +1 more source
Frontiers in Physiology, 2020 In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including
Weiyi Xu, Le Li, Le Li, Lilei Zhang
doaj +1 more source