Results 21 to 30 of about 29,739 (258)
Apprehending the NAD+–ADPr-Dependent Systems in the Virus World
Viruses, 2022 NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking.
Lakshminarayan M. Iyer +3 more
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Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure [PDF]
PeerJ, 2019 NAD glycohydrolase (EC 3.2.2.5) (NADase) sequences have been identified in 10 elapid and crotalid venom gland transcriptomes, eight of which are complete.
Ivan Koludarov, Steven D. Aird
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. [PDF]
PLoS ONE, 2014 Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration.
Blanca Arango-Gonzalez +16 more
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Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems
Challenges, 2018 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
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Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
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CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Mediators of Inflammation, 2018 Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande +6 more
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Nanomaterials, 2021 Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto +2 more
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Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht +6 more
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Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.
PLoS ONE, 2018 Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells.
Kizuku Watanabe +5 more
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Beilstein Journal of Organic Chemistry, 2015 Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was ...
Ahmed Mahal +9 more
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