Results 41 to 50 of about 29,739 (258)

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life [PDF]

, 2018
Metabolism is primed through the formation of thioesters via acetyl CoA and the phosphorylation of substrates by ATP. Prebiotic equivalents such as methyl thioacetate and acetyl phosphate have been proposed to catalyse analogous reactions at the origin ...
Camprubi, E, Herschy, B, Lane, N, Pinna, S, Whicher, A   +4 more
core   +1 more source

Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.

PLoS ONE, 2012
The ADPRibase-Mn-like protein family, that belongs to the metallo-dependent phosphatase superfamily, has different functional and structural prototypes.
Joaquim Rui Rodrigues, Ascensión Fernández, José Canales, Alicia Cabezas, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle   +6 more
doaj   +1 more source

Effects of NAD at purine receptors in isolated blood vessels [PDF]

, 2014
Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles.
Alefishat, Eman, Alexander, Stephen P.H., Ralevic, Vera   +2 more
core   +2 more sources

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

Molecules, 2011
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli, Vincenzo Piccialli, Luciano Mayol, Michela Varra, Jussara Amato, Nicola Borbone, Giorgia Oliviero, Stefano D’Errico   +7 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

‘Click cyclic ADP-ribose’: a neutral second messenger mimic [PDF]

Chem. Commun., 2014
Neutral synthetic analogues of the second messenger cADPR with a 1,2,3-triazole pyrophosphate bioisostere retain the ability to activate Ca2+release and to inhibit hydrolysis of cADPR by CD38.
Swarbrick, Joanna M., Graeff, Richard, Garnham, Clive, Thomas, Mark P., Galione, Antony, Potter, Barry V. L.   +5 more
openaire   +3 more sources

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source